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SULCONAZOLE

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SULCONAZOLE manufacturers

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  • 2021-07-17
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Related articles

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  • Mar 30,2022
SULCONAZOLE Basic information
Product Name:SULCONAZOLE
Synonyms:SULCONAZOLE;1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]- (9CI);1H-Imidazole, 1-[2-[[(4-chlorophenyl)methyl]thio]-2-(2,4-dichlorophenyl)ethyl]-, (+-)-;1-(2-((4-Chlorobenzyl)thio)-2-(2,4-dichlorophenyl)ethyl)-1H-iMidazole;Uniconazole sulfur nitrate;1-(2-((4-Chlorobenzyl);-2-(2,4-dichlorophenyl);1-{2-[(4-chlorobenzyl)sulfanyl]-2-(2,4-dichlorophenyl)ethyl}-1H-imidazole
CAS:61318-90-9
MF:C18H15Cl3N2S
MW:397.75
EINECS:
Product Categories:
Mol File:61318-90-9.mol
SULCONAZOLE Structure
SULCONAZOLE Chemical Properties
Boiling point 558.2±50.0 °C(Predicted)
density 1.34±0.1 g/cm3(Predicted)
storage temp. 2-8°C
pka6.55±0.12(Predicted)
CAS DataBase Reference61318-90-9
Safety Information
MSDS Information
SULCONAZOLE Usage And Synthesis
usesSulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
DefinitionChEBI: A member of the class of imidazoles that is 1-ethyl-1H-imidazole in which one of the hydrogens of the methyl group is replaced by a (4-chlorobenzyl)sulfanediyl group while a second is replaced by a 2,4-dichlorophenyl group.
IndicationsTopical treatment of mycoses of the skin induced or sustained by fungi such as dermatophytes and yeasts.
IndicationsSulconazole (Exelderm) is a synthetic, sulfur-substituted imidazole that is structurally related to the other imidazole antifungals (ketoconazole, econazole, and miconazole). It is postulated to inhibit 14-α-demethylase for decreased ergosterol synthesis, increased cell membrane permeability, and resultant cell death. It is active against most dermatophytes, yeast, and P. orbiculare. It also displays activity against some aerobic and anaerobic gram-positive bacteria. Sulconazole is a mild inducer of the cytochrome P-450 microsomal enzymes CYP1A1 and CYP2B1 and could theoretically induce the metabolism of other drugs.
Side effectsLocal irritations and allergic reactions may occur in rare cases and are mainly due to the galenic formulation.
SynthesisSulconazole, 1-[2,4-dichloro-|?-[(4-chlorobenzyl)thio]phenethyl]-imidazole (35.2.9), is an analog of exonazole. It differs in the replacement of the etheral oxygen bridge (which connects the 4-chlorobenzyl part of the molecule with phenethylimidazole) for a thioether bond. The corresponding changes in the synthesis of this drug are the replacement of the hydroxyl group in 1-(2,4-dichlorophenyl)-2-(1-imidazolyl)-ethanol (35.2.6) with a chlorine atom using thionyl chloride, followed by a reaction of the resulting chloride with 4-chlorobenzylmercaptane to make sulconazole.

Synthesis_61318-90-9

Solubility in organics1 part in 3,333 (water), 1 part in 100 (ethanol), 1 part in 130 (acetone), 1 part in 333 (chloroform), 1 part in 2000 (dioxan), 1 part in 71 (methanol), 1 part in 286(chloromethane), 1 part in 10 (pyridine), 1 part in 2000 (toluene).
SULCONAZOLE Preparation Products And Raw materials
Raw materialsTetrahydrofuran-->Thionyl chloride-->4-Chlorobenzyl chloride-->Potassium ethylxanthate-->Econazole-->Sulconazle Nitrate-->Miconazole
Tag:SULCONAZOLE(61318-90-9) Related Product Information
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