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SIGMA-RBI |
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800 736 3690 (Orders) |
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| | ANTI-P120CTN (CATENIN-RELATED) Basic information |
| | ANTI-P120CTN (CATENIN-RELATED) Chemical Properties |
| storage temp. | −20°C | | biological source | mouse |
| | ANTI-P120CTN (CATENIN-RELATED) Usage And Synthesis |
| Uses | Monoclonal Anti-p120ctn (Catenin-related) antibody produced in mouse has been used in:
- immunoblotting
- enzyme linked immunosorbent assay (ELISA),
- immunocytochemistry
- immunoprecipitation
| | Biological Activity | The 120 kD catenin-related protein p120ctn (also known as catenin p120ctn, p120cas and pp120 src substrate), was originally described as a prominent substrate for the sarcoma (Src) oncoprotein and for a variety of receptor tyrosine kinases (RTKs) including those for epidermal growth factor (EGF), platelet derived growth factor (PDGF), and colony stimulating factor-1 (CSF1). Like β-catenin and plakoglobin, it binds directly to the cytoplasmic domain of epithelial (E)-cadherin via the ARM domain and co-precipitates in multiprotein complexes containing E-cadherin or other cadherins such as neural (N)- or placental (P)- cadherins, depending on the cell type. However, unlike β-catenin and plakoglobin, p120ctn does not appear to bind α-catenin. |
| | ANTI-P120CTN (CATENIN-RELATED) Preparation Products And Raw materials |
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