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Dronedarone

Dronedarone Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Dronedarone
CAS:141626-36-0
Purity:99% Package:100g,500g,1kg,5kg,10kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:141626-36-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +86 21 5161 9050/ 5187 7795
Email: ivan@atkchemical.com
Products Intro: CAS:141626-36-0
Purity:0.99 Package:5G,10G,25G,50G,100G,250G,1KG
Company Name: career henan chemical co
Tel: +86-371-86658258
Email: sales@coreychem.com
Products Intro: Product Name:Dronedarone
CAS:141626-36-0
Purity:98% Package:1KG;1USD
Company Name: BOC Sciences
Tel: 1-631-619-7922
Email: inquiry@bocsci.com
Products Intro: Product Name:Dronedarone
CAS:141626-36-0
Purity:>98%

Lastest Price from Dronedarone manufacturers

  • Dronedarone
  • US $1.00-1.00 / KG
  • 2020-05-12
  • CAS:141626-36-0
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 50tons
  • Dronedarone
  • US $1.00 / KG
  • 2019-07-06
  • CAS:141626-36-0
  • Min. Order: 1KG
  • Purity: 98%
  • Supply Ability: 1kg,5kg,100kg
Dronedarone Basic information
Product Name:Dronedarone
Synonyms:Dronedarone;2-Butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-5-(methylsulfonamido)benzofuran;N-(2-Butyl-3-(4-(3-(dibutylamino)propoxy)benzoyl)-5-benzofuranyl)methanesulfonamide;N-(2-butyl-3-(4-(3-(dibutylaMino)propoxy)benzoyl)benzofuran-5-yl)MethanesulfonaMide;MethanesulfonaMide,N-[2-butyl-3-[4-[3-(dibutylaMino)propoxy]benzoyl]-5-benzofuranyl]-;N-[2-butyl-3-[4-[3-(dibutylamino)propoxy]benzoyl]-1-benzofuran-5-yl]methanesulfonamide;CS-294;Dronedarone (SR-33589)
CAS:141626-36-0
MF:C31H44N2O5S
MW:556.764
EINECS:
Product Categories:Cardiovascular APIs
Mol File:141626-36-0.mol
Dronedarone Structure
Dronedarone Chemical Properties
Melting point 65.3°
Boiling point 683.9±65.0 °C(Predicted)
density 1.143±0.06 g/cm3(Predicted)
pka7.40±0.30(Predicted)
CAS DataBase Reference141626-36-0(CAS DataBase Reference)
Safety Information
MSDS Information
Dronedarone Usage And Synthesis
DescriptionAF is the most common form of sustained cardiac arrhythmia, with an increasing prevalence in the aging population. AF accounts for 34.5% of arrhythmia-related hospital admissions in the United States. The most significant consequences of AF include congestive heart failure, a 5-fold increased risk of stroke, and increased rate of mortality. Although a 90% conversion rate from AF to normal sinus rhythm (NSR) can be achieved with electrical cardioversion, up to 70% of these patients require additional therapy with antiarrhythmic drugs in order to maintain NSR.
Dronedarone, a close analog of amiodarone, is structurally modified to provide improved safety and pharmacokinetic profile. With the introduction of a sulfonamide group, dronedarone is less lipophilic, has lower tissue accumulation, and has a much shorter serum half-life (~24 h) compared with amiodarone. Additionally, dronedarone lacks the iodine moieties that are responsible for thyroid dysfunctions associated with amiodarone. Dronedarone is specifically indicated to reduce the risk of cardiovascular hospitalization in patients with paroxysmal or persistent AF or AFL, with a recent episode of AF/AFL and associated cardiovascular risk factors, who are in sinus rhythm or who will be cardioverted. Similar to amiodarone, dronedarone is a potent blocker of multiple ion currents (including the rapidly activating delayed-rectifier potassium current, the slowly activating delayed-rectifier potassium current, the inward rectifier potassium current, the acetylcholine-activated potassium current, peak sodium current, and L-type calcium current) and exhibits antiadrenergic effects. Overall, dronedarone was well tolerated. The most common side effects were gastrointestinal in nature and included nausea, vomiting, and diarrhea.
OriginatorSanofi-Aventis (US)
DefinitionChEBI: A member of the class of 1-benzofurans used for the treatment of cardiac arrhythmias.
Brand nameMultaq
Dronedarone Preparation Products And Raw materials
Tag:Dronedarone(141626-36-0) Related Product Information
Triamterene Propafenone IBUTILIDE Sotalol Ranolazine ILOPERIDONE Dronedarone Hydrochloride 1-(2,6-Dimethylphenoxy)-2-propanamine 2-Butylbenzofuran 3-(4-HYDROXYBENZOYL)-2-METHYL-BENZOFURAN 2-METHYL-5-BENZOFURANAMINE Benzarone 1-BENZOFURAN-5-AMINE 2-Butyl-3-(4-hydroxybenzoyl)benzofuran 3-Acetyl-2-ethylbenzofuran Dronedarone 3-ACETYLBENZO[B]FURAN 2-Ethylbenzofuran-3-carbaldehyde