达佐必利
| 中文名称 | 达佐必利 |
|---|---|
| 中文同义词 | 达佐必利;化合物 T10963 |
| 英文名称 | Dazopride |
| 英文同义词 | Dazopride;4-Amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxybenzamide;4-amino-5-chloro-N-(1,2-diethylpyrazolidin-4-yl)-2-methoxybenzamide;AHR-5531;Benzamide, 4-amino-5-chloro-N-(1,2-diethyl-4-pyrazolidinyl)-2-methoxy- |
| CAS号 | 70181-03-2 |
| 分子式 | C15H23ClN4O2 |
| 分子量 | 326.82 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 70181-03-2.mol |
| 结构式 |  |
达佐必利 性质
| 密度 | 1.27±0.1 g/cm3(Predicted) |
|---|---|
| 储存条件 | Store at -20°C |
| 溶解度 | 溶于二甲基亚砜 |
| 酸度系数(pKa) | 13.31±0.20(Predicted) |
Dazopride (0.3 mg/kg) produces significant enhancement of gastric evacuation and is approximately six times more potent than metoclopramide in gastric evacuation assay. Dazopride (0.3-10.0 mg/kg, i.v.) produces a dose-related increase in antral motility primarily by increasing the amplitude of antral contractions in three conscious dogs. Dazopride significantly reduces the emetic frequency from that of the control group. Dazopride (5 mg/kg, i.p.) antagonises the tetralin-induced emesis in all animals, but fails to antagonise the response at 0.25-2.5 mg/kg. Dazopride fails to modify cisplatin-induced emesis at 0.1 mg/kg (i.v,) although a larger dose of 1.0 mg/kg abolishes or attenuates the response and 5.0 mg/kg of dazopride antagonises the development ofemesis in all animals.