| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
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| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:GRANZYME B
CAS:143180-74-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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| Company Name: |
Wuhan Chemstan Biotechnology Co., Ltd.
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| Tel: |
15926423062 |
| Email: |
422450190@qq.com |
| Products Intro: |
Product Name:Recombinant Mouse Gzmb Protein, His Tag
Purity:90% as determined by SDS-PAGE Package:50ug;100ug
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| Company Name: |
Shanghai Huzhen Industrial Co., LTD
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| Tel: |
021-60345367 13916550749 |
| Email: |
sales@shzbio.com |
| Products Intro: |
Product Name:Granzyme B
Purity:> 99% Package:50ul/RMB 1098;100ul/RMB 1880;200ul/RMB 2900 Remarks:GranzymeB; Granzyme-B; C11; Cathepsin G-like 1; CTLA-1
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| Company Name: |
AntibodySystem
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| Tel: |
027-65279366 18162686757 |
| Email: |
biolab-reagents@atagenix.com |
| Products Intro: |
Product Name:GZMB
Purity:95% SDS-PAGE Package:1mg;100ug
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| | GRANZYME B Basic information |
| Product Name: | GRANZYME B | | Synonyms: | EC 3.4.21.79;GRANZYME B (HUMAN);GRANZYME B, HUMAN, CELL CULTURE-DERIVED;GRANZYME B ENZYME;GRANZYME B;GZMB;SensiZyme Granzyme B Activity Assay Kit;Granzyme B from mouse | | CAS: | 143180-74-9 | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![GRANZYME B Structure]() |
| | GRANZYME B Chemical Properties |
| storage temp. | -70°C | | form | buffered aqueous solution |
| Risk Statements | 42/43 | | Safety Statements | 26-36 | | WGK Germany | - |
| | GRANZYME B Usage And Synthesis |
| General Description | Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations. | | Biochem/physiol Actions | Cytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way. |
| | GRANZYME B Preparation Products And Raw materials |
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