GRANZYME B

GRANZYME B Suppliers list
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:143180-74-9
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Creative Enzymes
Tel: 1-631-619-7922
Email: info@creative-enzymes.com
Products Intro: Product Name:granzyme B
CAS:143180-74-9
Purity:Partially purified by single-step affinity chromatography an Remarks:From cytotoxic T lymphocyte granules. In peptidase family S1 (trypsin family)
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801
Email: 3bsc@sina.com
Products Intro: Product Name:GRANZYME B
CAS:143180-74-9
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: Wuhan Chemstan Biotechnology Co., Ltd.  
Tel:
Email: 422450190@qq.com
Products Intro: Product Name:Recombinant Mouse Gzmb Protein, His Tag
Purity:90% as determined by SDS-PAGE Package:50ug;100ug
Company Name: 维克里奇化学公司  
Tel: (973)344-1818
Email: info@veckridge.com
Products Intro: Product Name:Enzymes
CAS:143180-74-9
GRANZYME B Basic information
Product Name:GRANZYME B
Synonyms:EC 3.4.21.79;GRANZYME B (HUMAN);GRANZYME B, HUMAN, CELL CULTURE-DERIVED;GRANZYME B ENZYME;GRANZYME B;GZMB;SensiZyme Granzyme B Activity Assay Kit;Granzyme B from mouse
CAS:143180-74-9
MF:
MW:0
EINECS:
Product Categories:
Mol File:Mol File
GRANZYME B Structure
GRANZYME B Chemical Properties
storage temp. -70°C
form buffered aqueous solution
Safety Information
Risk Statements 42/43
Safety Statements 26-36
WGK Germany -
MSDS Information
ProviderLanguage
SigmaAldrich English
GRANZYME B Usage And Synthesis
General Description
Granzyme B, a 247 amino acid polypeptide, contains a leader sequence, which is cleaved by a signal peptidase and a two amino acid prodomain, which is cleaved by the lysosomal cysteine protease DPPI. The recombinant granzyme B is expressed in Pichia pastoris as the mature form and appears on SDS-PAGE as a triplet (~34, 32, and 30 kDa) due to three different glycosylations.
Biochem/physiol ActionsCytotoxic granules secreted by natural killer (NK) cells and cytotoxic T Lymphocytes cells are part of the mechanism used for protecting the organism from virus infected and tumor cells. Granzyme B, a serine protease, is the most prominent granzyme in a family of 11 found in the cytotoxic granules. The granzymes enter the target cell with the assistance of perforin, a critical molecule of the cytotoxic granules. In the target cell, the granzymes act on specific substrates involved with the cell death via apoptosis.Granzyme B is a neutral serine protease that cleaves aspartic acid residues, inducing cell death by various pathways. It can cleave and activate most of the caspases in vitro and in vivo resulting in a massive amplification of the caspase dependent apoptotic pathway. In addition, granzyme B cleaves directly downstream caspase substrates as PARP DNA-PK2 and DFF45/ICAD leading to cell death. This pathway bypasses inhibition of apoptosis by viral caspase inhibitors found in virus infected cells. It has been shown that granzyme B is capable of inducing cytochrome C release from the mitochondria in a caspase independent way.
GRANZYME B Preparation Products And Raw materials
Tag:GRANZYME B(143180-74-9) Related Product Information
Granzyme B, 31kD, Clone: CLB-GB11, Mab anti-Human, Chimpanzee, Rhesus, Biotin, flow ANTI-GRANZYME A (15-25), HUMAN Granzyme B, 31kD, Clone: CLB-GB11, Mab anti-Human, Chimpanzee, Rhesus, RPE, flow GRANZYME B SUBSTRATE,GRANZYME B SUBSTRATE IV 2,4-PENTANEDIONE, SILVER DERIVATIVE N-BUTYLISOCYANIDE Ethyl isocyanoacetate Cupric acetylacetonate Ferric acetylacetonate COBALT(II) ACETYLACETONATE Tris(2,4-pentanedionato)chroMiuM(III) Aluminum acetylacetonate COBALT ETHYLENE DIAMINE CHLORIDE METHYL ISOCYANOACETATE Tosylmethyl isocyanide DICHLORO(ETHYLENEDIAMINE)PLATINUM(II) TRIS(2,2,6,6-TETRAMETHYL-3,5-HEPTANEDIONATO)EUROPIUM(III) TERT-BUTYL ISOCYANIDE