AGM-1470

AGM-1470 Suppliers list
Company Name: BOC Sciences
Tel: 1-631-485-4226
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Products Intro: Product Name:AGM-1470
CAS:129298-91-5
Purity:>97.0%
Company Name: CONIER CHEM AND PHARMA LIMITED
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Products Intro: Product Name:agm-1470
CAS:129298-91-5
Purity:0.99 Package:1kg
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897、88216896 13588875226
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Products Intro: Product Name:TNP-470
CAS:129298-91-5
Purity:83899% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 821-50328103-801
Email: 3bsc@sina.com
Products Intro: Product Name:TNP 470;N-(2-Chloroacetyl)carbaMicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-Methyl-3-(3-Methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
CAS:129298-91-5
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Company Name: BOC Sciences  
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Products Intro: Product Name:TNP-470
CAS:129298-91-5
Purity:≥98% Remarks:TNP-470 is an analog of fumagillin, an antimicrobial agent isolated from the fungus Aspergillus fumigatus. TNP-470 was shown to inhibit angiogenesis, and irreversibly suppress methionine aminopeptidas
AGM-1470 Basic information
Product Name:AGM-1470
Synonyms:NSC642492;O-(chloroacetylcarbamoyl)fumagillol;O-(CHLOROACETYLCARBAMOYL)FUMAGILLOLTNP-470 AGM-1470;[(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methylbut-2-enyl)oxiran-2-yl]-1-oxaspiro[2.5]octan-6-yl] N-(2-chloroacetyl)carbamate;AGM-1470;Carbamic acid, (chloroacetyl)-, (3R,4S,5S,6R)-5-methoxy-4-[ (2R,3R)-2-methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5]oct-6-yl ester;Tnp-470;N-(2-Chloroacetyl)carbamicacid(3R,4S,5S,6R)-5-Methoxy-4-[(2R,3R)-2-methyl-3-(3-methyl-2-buten-1-yl)-2-oxiranyl]-1-oxaspiro[2.5]oct-6-ylester
CAS:129298-91-5
MF:C19H28ClNO6
MW:401.88
EINECS:
Product Categories:
Mol File:129298-91-5.mol
AGM-1470 Structure
AGM-1470 Chemical Properties
alpha D24 -46.6° (c = 0.44 in CHCl3)
density 1.26±0.1 g/cm3(Predicted)
storage temp. -20°C
solubility DMSO: >15mg/mL
pka7.19±0.46(Predicted)
form White to light yellow solid
CAS DataBase Reference129298-91-5
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38
Safety Statements 26
WGK Germany 2
MSDS Information
AGM-1470 Usage And Synthesis
DescriptionTNP-470 is a synthetic analog of fumagillin (Item No. 11332) that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
UsesTNP-470 is a synthetic analog of fumagillin that inhibits angiogenesis. It irreversibly inactivates methionine aminopeptidase-2 (MetAP2; IC50 = 2 μM), blocking endothelial cell proliferation in vitro and angiogenesis in vivo. It is without effect on MetAP1. TNP-470 has therapeutic potential in cancer and microsporidiosis.
UsesTNP-470 is a synthetic analog of Fumagillin (F862650); a compound isolated from the fungus Aspergillus fumigatus. Fumagillin is an antimicrobial agent used in the treatment of microsporidiosis and shows promise as both an anti-infective and antiangiogenic agent.
DefinitionChEBI: A carbamate ester that is fumagillol in which the hydroxy group has been converted to the corresponding N-(chloroacetyl)carbamate derivative.
General Description
TNP-470 is a synthetic analogue of fumagillin. It is a natural product of Aspergillus fumigatus. TNP-470 serves as an angiogenesis inhibitor.
Biological ActivityAnalog of Fumagillin ((2E,4E,6E,8E)-Mono[(3R,4S,5S,6R)-5-methoxy-4-[(2R,3R)-2 -methyl-3-(3-methyl-2-butenyl)oxiranyl]-1-oxaspiro[2.5] oct-6-yl] 2,4,6,8-decatetraenedioic acid ester) that displays potent antiangiogenic activity in vitro and in vivo . Inhibits methionine aminopeptidase type II (MetAP2).
Biochem/physiol ActionsTNP-470 is a methionine aminopeptidase-2 (MetAP-2) inhibitor, selective for MetAP-2 over MetAP11. TNP-470 is an antiangiogenic.
AGM-1470 Preparation Products And Raw materials
Tag:AGM-1470(129298-91-5) Related Product Information
Methyl bromide Thiophanate-methyl Tribenuron methyl METSULFURON METHYL Styrene oxide ETHYLENE OXIDE Methyl acetate fumagillol Sineptina FUMAGILLIN METHYL CHLOROACETYLCARBAMATE 1,2,4,5-DIEPOXYPENTANE N-CHLOROACETYL URETHANE AGM-1470 Midecamycin Acetate Acetylspiramycin Methoxy Methyl