| Company Name: |
Tianjin Kailiqi Biotechnology Co., Ltd.
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| Tel: |
15076683720 |
| Email: |
klq@cw-bio.com |
| Products Intro: |
Product Name:Aurora Kinases-IN-2
CAS:2241914-86-1
Purity:大于98% Package:1g,5g,10g,25g根据客户需要分装 Remarks:Not For Human Use, Lab Use Only.
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| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:Aurora Kinases-IN-2
CAS:2241914-86-1
Package:25mg/RMB 10600;50mg/RMB 13800;100mg/RMB 17500
|
Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- manufacturers
- Aurora Kinases-IN-2
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- $1520.00 / 25mg
-
2025-10-27
- CAS:2241914-86-1
- Min. Order:
- Purity:
- Supply Ability: 10g
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| | Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- Basic information |
| | Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- Chemical Properties |
| Boiling point | 534.7±50.0 °C(Predicted) | | density | 1.390±0.06 g/cm3(Predicted) | | pka | 12.26±0.70(Predicted) |
| | Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- Usage And Synthesis |
| Uses | Aurora kinase-IN-2 (compound 12Aj) is a potent Aurora kinase inhibitor with IC50 values of 90 and 152 nM for Aurora A and Aurora B. Aurora kinase-IN-2 arrests cell cycle at G2/M phase by regulating cyclin B1 and cdc2. Aurora kinase-IN-2 can be used for cancer research[1]. | | IC 50 | Aurora A: 90 nM (IC50); Aurora B: 152 nM (IC50) | | References | [1] Bo YX, et, al. Synthesis, biological evaluation and molecular modeling study of 2-amino-3,5-disubstituted-pyrazines as Aurora kinases inhibitors. Bioorg Med Chem. 2020 Mar 1;28(5):115351. DOI:10.1016/j.bmc.2020.115351 |
| | Benzamide, 4-[[3-amino-6-(3,5-dimethyl-4-isoxazolyl)-2-pyrazinyl]oxy]-N-(3-chlorophenyl)- Preparation Products And Raw materials |
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