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Poly(ethylene glycol) distearate

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CAS:9005-08-7
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CAS:9005-08-7
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Products Intro: Product Name:Poly(ethylene glycol) distearate
CAS:9005-08-7
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Poly(ethylene glycol) distearate manufacturers

Poly(ethylene glycol) distearate Basic information
Product Name:Poly(ethylene glycol) distearate
Synonyms:DIETHYLENE GLYCOL DISTEARATE;DGD;Polyethyleneglycol3distearate;polyethyleneglycoldistearate#1000;polyglycoldistearate;s1009;s1013;stabogel
CAS:9005-08-7
MF:C19H40O4
MW:332.5185
EINECS:
Product Categories:Cosmetic Ingredients & Chemicals
Mol File:9005-08-7.mol
Poly(ethylene glycol) distearate Structure
Poly(ethylene glycol) distearate Chemical Properties
Melting point 35-37 °C
Fp >230 °F
Odorat 100.00?%. mild waxy
Dielectric constant2.3(0.0℃)
LogP5.997 (est)
CAS DataBase Reference9005-08-7
EPA Substance Registry SystemPolyethylene glycol distearate (9005-08-7)
Safety Information
WGK Germany 1
RTECS TQ4375000
MSDS Information
ProviderLanguage
SigmaAldrich English
Poly(ethylene glycol) distearate Usage And Synthesis
Chemical PropertiesA soft, off-white solid. PH of 10% dispersion 7.26, saponification number variable. Soluble in chlorinated solvents, light esters, and acetone; slightly soluble in alcohols, insoluble in glycols, hydrocarbons, and vegetable oils. Combustible.
UsesPegosperse(R) 300 DS is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.
UsesPOLY(ETHYLENE GLYCOL) (N) DISTEARATE is used as an emulsifier for personal care and water treatment and as a processing aid in textile industry.
DefinitionDistearate ester of polyglycol.
Production MethodsPolyethylene glycol distearate is prepared by the direct reaction of fatty acids, particularly stearic acid, with ethylene oxide.
Pharmaceutical ApplicationsPolyethylene glycol distearate is generally used as emulsifiers in oil-inwater- type creams and lotions. Its hydrophilicity or lipophilicity depends on the number of ethylene oxide units present: the larger the number, the greater the hydrophilic properties. Polyoxyl 40 stearate has been used as an emulsifying agent in intravenous infusions.
Polyoxyethylene stearates are particularly useful as emulsifying agents when astringent salts or other strong electrolytes are present. It can also be blended with other surfactants to obtain any hydrophilic–lipophilic balance for lotions or ointment formulations.
Safety ProfilePoison by intravenous route. When heated to decomposition it emits acrid smoke and irritating fumes. See also POLYETHYLENE GLYCOL.
SafetyAlthough Polyethylene glycol distearate is primarily used as emulsifying agents in topical pharmaceutical formulations, certain materials, particularly polyoxyl 40 stearate, have also been used in intravenous injections and oral preparations.
Polyethylene glycol distearate has been tested extensively for toxicity in animals(8–13) and are widely used in pharmaceutical formulations and cosmetics. It is generally regarded as essentially nontoxic and nonirritant materials.
Polyoxyl 8 stearate
(hamster, oral): 27 g/kg
(rat, oral): 64 g/kg
Polyoxyl 20 stearate
(mouse, IP): 0.2 g/kg
(mouse, IV): 0.87 g/kg
storagePolyoxyethylene stearates are generally stable in the presence of electrolytes and weak acids or bases. Strong acids and bases can cause gradual hydrolysis and saponification.
The bulk material should be stored in a well-closed container, in a dry place, at room temperature.
IncompatibilitiesPolyethylene glycol distearate is unstable in hot alkaline solutions owing to hydrolysis, and will also saponify with strong acids or bases. Discoloration or precipitation can occur with salicylates, phenolic substances, iodine salts, and salts of bismuth, silver, and tannins.Complex formation with preservatives may also occur.The antimicrobial activity of some materials such as bacitracin, chloramphenicol, phenoxymethylpenicillin, sodium penicillin, and tetracycline may be reduced in the presence of polyoxyethylene stearate concentrations greater than 5% w/w.
Regulatory StatusIncluded in the FDA Inactive Ingredients Database (dental solutions; IV injections; ophthalmic preparations; oral capsules and tablets; otic suspensions; topical creams, emulsions, lotions, ointments, and solutions; and vaginal preparations). Included in nonparenteral medicines licensed in the UK. Included in the Canadian List of Acceptable Non-medicinal Ingredients.
Poly(ethylene glycol) distearate Preparation Products And Raw materials
Raw materialsStearic acid
Tag:Poly(ethylene glycol) distearate(9005-08-7) Related Product Information
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