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Sumatriptan succinate

Sumatriptan succinate Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Sumatriptan succinate
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:103628-48-4
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Products Intro: Product Name:Sumatriptan succinate
Company Name: Xiamen AmoyChem Co., Ltd
Tel: +86 (0)592-605 1114
Products Intro: Product Name:Sumatriptan succinate
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Products Intro: CAS:103628-48-4
Purity:99% Package:5KG;1KG;25KG PRICE quotation Remarks:Factory stock, quality assurance, price concessions

Lastest Price from Sumatriptan succinate manufacturers

  • Sumatriptan succinate
  • US $2.00 / kg
  • 2019-05-13
  • CAS:103628-48-4
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 100kg
Sumatriptan succinate Basic information
Description References
Product Name:Sumatriptan succinate
Synonyms:SuMatriptan Succinate, EP;Sumatriptan Succinate (200 mg);SuMitrex;3-[2-(Dimethylamino)ethyl]-1H-indol-5-yl-N-methylmethanesulfonamide Succinate;(3-(2-(dimethylamino)ethyl)-1H-indol-5-yl)-N-methylmethanesulfonamide succinic acid;3-[2-(DIMETHYLAMINO) ETHYL]-N-METHYL-1H-INDOLE-5-METHANE SULFONAMIDE;3-[2-(Dimethylamino)ethyl]-N-methyl-1H-indole-5-methanesulfonamide, Succinate, Imigran, Imitrex,;Butanedioic acid, compd. with 3-2-(dimethylamino)ethyl-N-methyl-1H-indole-5-methanesulfonamide (1:1)
Product Categories:-;Serotonin receptor;Indoles and derivatives;Inhibitors;Intermediates & Fine Chemicals;OPTIMINE;Pharmaceuticals;Sumatriptan
Mol File:103628-48-4.mol
Sumatriptan succinate Structure
Sumatriptan succinate Chemical Properties
Melting point 165-166°C
storage temp. Store at +4°C
solubility H2O: >20mg/mL
form solid
color white to off-white
Merck 14,8997
CAS DataBase Reference103628-48-4(CAS DataBase Reference)
Safety Information
Hazard Codes Xi
Risk Statements 36/37/38-41
Safety Statements 26-36-39
WGK Germany 3
RTECS EJ9940000
HS Code 29350090
MSDS Information
Sumatriptan succinate Usage And Synthesis
DescriptionSumatriptan succinate is a synthetic drug belonging to a class of medications known as 5-hydroxytryptamine agonists (also called "triptans"), which is commonly used to treat cluster and migraine headaches with or without aura (warning signs occurring prior to the onset of a migraine). It is effective to relieve or eliminate the intensity of migraine and cluster headaches and accompanying symptoms including sensitivity to light or sound, nausea, and vomiting. However, it cannot help prevent future migraines/headaches or decrease the frequency of getting migraine and it is not recommended for other types of headache or for headache prevention.
It is believed that the pain of migraine headaches is induced by dilated blood vessels inside the head. Sumatriptan succinate relieves migraine headaches by affecting the serotonin in the brain, which results in constriction of blood vessels. Subcutaneous injection of this drug is more effective than other formulations.
DescriptionSumatriptan succinate is a highly selective 5HT1-like receptor agonist introduced as a new treatment for migraine. It is indicated for the acute relief of migraine and cluster headache. Oral administration is reported to be free of substantial side effects. The compound appears to be a significant advance over the use of ergotamine and other agents in the treatment of migraine.
Chemical PropertiesWhite Crystalline Powder
OriginatorGlaxo (United Kingdom)
UsesSumatriptan (succinate) is a serotonin 5-hydroxytryptamine 1 (5-HT1) receptor agonist with selective affinity for 5-HT1B and 5-HT1D receptors with IC50 values of 9.3 and 7.3 nM, respectively. It also has affinity for the 5-HT1F receptor (IC50 = 17.8 nM). Sumatriptan (succinate) has been shown to induce vasoconstriction of human middle meningeal arteries (EC50 = 89.9 nM) and reduce vascular inflammation associated with migraines.
UsesA serotonin 5HT1-receptor agonist
UsesA selective 5-HT1 receptor agonist
DefinitionChEBI: A succinate salt obtained by reaction of sumatriptan with one equivalent of succinic acid. Selective agonist for a vascular 5-HT1 receptor subtype (probably a member of the 5-HT1D family). Used for the acute treatm nt of migraine with or without aura in adults.
Brand nameImitrex (GlaxoSmithKline);Imigran.
World Health Organization (WHO)Suprofen, a nonsteroidal anti-inflammatory agent, was introduced in 1983 for use as an analgesic for the symptomatic relief of mild to moderate pain and for primary dysmenorrhoea. By 1986 it had become evident that its use was occasionally associated with flank pain sometimes accompanied by evidence of decreased renal function. The Arthritis Advisory Committee of the United States Food and Drug Administration met in December 1986 to review the situation and decided against withdrawing suprofen from the market. However, in May 1987 the Committee for Proprietary Medicinal Products of the European Community recommended that all marketing authorizations should be suspended. The manufacturer subsequently decided to suspend sale worldwide on the grounds that sales had diminished to the point where the product was no longer economically viable.
Biological ActivitySelective 5-HT 1 receptor agonist (K i values are 17, 27 and 100 nM at 5-HT 1D , 5-HT 1B and 5-HT 1A receptors respectively). Antimigraine agent.
Sumatriptan succinate Preparation Products And Raw materials
Preparation ProductsSumatriptan
Tag:Sumatriptan succinate(103628-48-4) Related Product Information
Kresoxim-methyl Methyl salicylate 6alpha-Methylprednisolone sodium succinate Zolmitriptan Rizatriptan Sumatriptan iron succinate Succinic acid Sumatriptan succinate Parathion-methyl Thiophanate-methyl Methyl bromide Methyl acetate 2-[[[[(4-Methoxy-6-methyl-1,3,5-triazin-2-yl)amino]carbonyl]amino]sulfonyl]benzoic acid methyl ester Tribenuron methyl Sulfanilamide Disodium succinate p-Toluenesulfonamide