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BOC Sciences
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| Products Intro: |
Product Name:CGP 48369
CAS:135689-23-5
Purity:98% Remarks:Reach out to us for more information about custom solutions.
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CGP 48369 manufacturers
- CGP48369
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- $700.00 / 1mg
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2025-10-27
- CAS:135689-23-5
- Min. Order:
- Purity: 99.27%
- Supply Ability: 10g
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| | CGP 48369 Basic information |
| Product Name: | CGP 48369 | | Synonyms: | CGP 48369;4(3H)-Pyrimidinone, 2,6-dibutyl-5-[[2'-(2H-tetrazol-5-yl)[1,1'-biphenyl]-4-yl]methyl]-;CGP-48369,CGP48369 | | CAS: | 135689-23-5 | | MF: | C26H30N6O | | MW: | 442.56 | | EINECS: | | | Product Categories: | | | Mol File: | 135689-23-5.mol |  |
| | CGP 48369 Chemical Properties |
| Boiling point | 653.2±65.0 °C(Predicted) | | density | 1.22±0.1 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | Soluble in DMSO | | pka | 4.17±0.10(Predicted) |
| | CGP 48369 Usage And Synthesis |
| Uses | CGP48369 is a nonpeptidic angiotensin II receptor antagonist, used for anti-hypertensive research. | | in vivo | CGP48369 (10 mg/kg/day p.o.) decreases BP in two-kidney/one-clip renal hypertensive rats for at least 24 h. In arteries with endothelium, contractions induced by AII 3×10-8 M do not differ in untreated spontaneously hypertensive rats (SHR) and WKY. All evoked significantly smaller contractions in SHR treated with CGP 48369 than in the other treated SHR. Antihypertensive treatment with benazepril or nifedipine, and to a lesser extent with CGP 48369, increases the sensitivity (pD2-va1ue) to intraluminal ACh. In arteries without endothelium, sensitivity to NE is identical in all groups, whereas maximal response in CGP 48369-treated SHR and in nifedipine treated SHR is slightly greater as compared with that in WKY[1]. In SHR, antihypertensive therapy with either benazepril HCl, CGP 48369, valsartan, or nifedipine (each 10 mg/kg/d for 8 weeks) significantly increase endothelium-dependent relaxations evoked by acetylcholine[2]. | | References | [1] Dohi Y, et al. Angiotensin blockade or calcium antagonists improve endothelial dysfunction in hypertension: studies in perfused mesenteric resistance arteries. J Cardiovasc Pharmacol. 1994 Sep;24(3):372-9. DOI:10.1097/00005344-199409000-00004
[2] Tschudi MR, et al. Antihypertensive therapy augments endothelium-dependent relaxations in coronary arteries of spontaneously hypertensive rats. Circulation. 1994 May;89(5):2212-8. DOI:10.1161/01.cir.89.5.2212 |
| | CGP 48369 Preparation Products And Raw materials |
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