| Company Name: |
Shanghai Yifei Biotechnology Co. , Ltd.
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| Tel: |
021-65675885 18964387627 |
| Email: |
customer_service@efebio.com |
| Products Intro: |
Product Name:AMX12006
CAS:2639775-01-0
Purity:95% Package:1mg;5mg;10mg
|
| Company Name: |
TargetMol Chemicals Inc.
|
| Tel: |
15002134094 |
| Email: |
marketing@targetmol.cn |
| Products Intro: |
Product Name:AMX12006
CAS:2639775-01-0
Package:10mg/RMB 7850;5mg/RMB 4420;1mg/RMB 997
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| Company Name: |
Cayman Chemical Company
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| Tel: |
800-364-9897 |
| Email: |
sales@caymanchem.com |
| Products Intro: |
Product Name:AMX12006
|
| Company Name: |
Neobioscience Co., Ltd.
|
| Tel: |
4006-800-892 |
| Email: |
info@neobioscience.com |
| Products Intro: |
Product Name:AMX12006
|
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| | AMX12006 Basic information |
| Product Name: | AMX12006 | | Synonyms: | AMX12006;Benzoic acid, 4-[(1S)-1-[[[1-methyl-3-[[3-(trifluoromethyl)phenyl]amino]-1H-indol-2-yl]carbonyl]amino]ethyl]- | | CAS: | 2639775-01-0 | | MF: | C26H22F3N3O3 | | MW: | 481.47 | | EINECS: | | | Product Categories: | | | Mol File: | 2639775-01-0.mol |  |
| | AMX12006 Chemical Properties |
| Boiling point | 689.070±55.00 °C(Press: 760.00 Torr)(predicted) | | density | 1.334±0.14 g/cm3(Temp: 25 °C; Press: 760 Torr)(predicted) | | solubility | DMF: 20 mg/ml
DMSO: 10 mg/ml
Ethanol: 1 mg/ml | | pka | 4.242±0.10(predicted) |
| | AMX12006 Usage And Synthesis |
| Uses | AMX12006 is a potent, selective and orally active EP4 antagonist with an IC50 value of 4.3 nM. AMX12006 shows cytotoxic and antitumor activity[1]. | | in vivo | AMX12006 (75, 150 mg/kg; p.o.; once daily for 11 days) shows antitumor activity in a dose-dependent manner[1].
Pharmacokinetic Parameters of AMX12006 in Sprague-Dawley rats[1].
| iv, 1 mg/kg | po, 10 mg/kg | | Tmax (h) | | 0.5 | | Cmax (ng/mL) | 4627 ± 304 | 8243 ± 370 | | AUC(0-t)(h·ng/mL) | 3375 ± 477 | 25672 ± 5668 | | AUC0–∞ (h·ng/mL) | 3416 ± 495 | 25707 ± 5682 | | T1/2(h) | 1.4 ± 0.3 | 2.7 ± 0.2 | | CL (mL/min/kg) | 4.95 ± 0.77 | | | Vdss (L/kg) | 0.41 ± 0.04 | | | F % | | 76.1 |
Sprague-Dawley rats, 1 mg/kg iv ; 10 mg/kg po [1] | | IC 50 | hEP4: 4.3 nM (IC50) | | References | [1] Debasis Das, et al. Discovery of Novel, Selective Prostaglandin EP4 Receptor Antagonists with Efficacy in Cancer Models. ACS Med. Chem. Lett. 2023. |
| | AMX12006 Preparation Products And Raw materials |
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