- 5-Bromoisatin
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- $0.00 / 1KG
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2022-02-19
- CAS:87-48-9
- Min. Order: 1KG
- Purity: 98.9%
- Supply Ability: 100 tons
- 5-Bromoisatin
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- $15.00 / 1KG
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2021-08-12
- CAS:87-48-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- 5-Bromoisatin
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- $1.00 / 1KG
-
2019-07-06
- CAS:87-48-9
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1kg,5kg,100kg
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| | 5-Bromoisatin Basic information |
| | 5-Bromoisatin Chemical Properties |
| Melting point | 247-252 °C (lit.) | | density | 1.7498 (rough estimate) | | refractive index | 1.6120 (estimate) | | storage temp. | Sealed in dry,Room Temperature | | solubility | Soluble in N,N dimethylformamide. | | pka | 8.74±0.20(Predicted) | | form | Crystalline Powder | | color | Orange | | BRN | 383760 | | InChIKey | MBVCESWADCIXJN-UHFFFAOYSA-N | | CAS DataBase Reference | 87-48-9(CAS DataBase Reference) |
| Hazard Codes | Xi | | Risk Statements | 37/38-41 | | Safety Statements | 26-36/39-37/39-36 | | RIDADR | 2811 | | WGK Germany | 2 | | RTECS | NL7875000 | | Hazard Note | Irritant | | HS Code | 29337900 |
| | 5-Bromoisatin Usage And Synthesis |
| Chemical Properties | Orange crystalline powder | | Uses | 5-Bromoisatin is used in the synthesis of N-derivatives of 5-bromoisatin, N-substituted pyrroles, linear polyaryleneoxindoles, 5-bromodioxindole, cinchoninic acid derivatives, 3-hydroxyoxindole, S-benzyldithiocarbazate Schiff Bases, 5-bromooxindole and Morita-Baylis-Hillman adducts of isatin derivatives. It is an indole derivative. | | Definition | ChEBI: 5-Bromoisatin is a member of indoles. It has a role as an anticoronaviral agent. | | Synthesis Reference(s) | Tetrahedron Letters, 25, p. 3099, 1984 DOI: 10.1016/0040-4039(84)80017-9 | | General Description | 5-Bromoisatin is a 5-haloisatin. One of the methods reported for its synthesis is by reacting N-halosaccharins with isatin in the presence of SiO2. Its inotropic activity has been studied on rhythmically stimulated papillary muscles of guinea pigs. It is reported to exhibit analgesic and sedative properties at a dose of 0.2g/kg in mice. | | Purification Methods | 5-Bromoisatin forms red prisms or needles from EtOH. The N-acetate crystallises as yellow prisms from *C6H6, m 170-172o, and the N-methyl derivative forms orange-red needles from MeOH, m 172-173o. [Heller Chem Ber 53 1545 1920, Buu-Hoi Recl Trav Chim, Pays-Bas 73 197 1954, Baker etal. Tetrahedron Lett 215 1978, Beilstein 21 H 453, 21 III/IV 5009.] |
| | 5-Bromoisatin Preparation Products And Raw materials |
| Preparation Products | 5-Bromoisatoic anhydride-->6-BROMO-3-HYDROXYQUINOLINE-->5-NITROISATOIC ANHYDRIDE-->6-Bromoisatinic anhydride-->5-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL) INDOLIN-2-ONE-->5-BROMO-1H-INDAZOLE-3-CARBALDEHYDE-->6-BROMO-2-(4-BROMO-PHENYL)-QUINOLINE-4-CARBOXYLIC ACID-->7-BROMO-1,2,3,4-TETRAHYDRO-ACRIDINE-9-CARBOXYLIC ACID-->4-Quinolinecarboxylic acid, 6-bromo-2-(2-fluoro-5-methylphenyl)--->4-Quinolinecarboxylic acid, 6-bromo-2-(4-fluoro-2-methylphenyl)--->Hydrazinecarbothioamide, 2-(5-bromo-1,2-dihydro-2-oxo-3H-indol-3-ylidene)--->5-BROMO-1H-INDAZOLE-3-CARBOXYLIC ACID-->5-bromo-1-ethyl-1H-indole-2,3-dione |
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