ChemicalBook > Product Catalog >Organic Chemistry >Heterocyclic Compounds >1-Amino-2-methylpropan-2-ol

1-Amino-2-methylpropan-2-ol

1-Amino-2-methylpropan-2-ol Suppliers list
Company Name: BTC pharm India
Tel: +918790379245
Email: banny.janga@btcpharm.com
Products Intro: Product Name:1-Amino-2-methylpropan-2-ol
CAS:2854-16-2
Purity:98+ Package:5 kg, 25 kg, 100 kg and 1 MT
Company Name: Hebei Chuanghai Biotechnology Co., Ltd
Tel: +8615350571055
Email: Sibel@chuanghaibio.com
Products Intro: Product Name:1-Amino-2-methylpropan-2-ol
CAS:2854-16-2
Purity:99% Package:1kg;10.00;USD
Company Name: Sichuan Zhuoyu Yantang Technology Co., Ltd.
Tel: +8613288715578
Email: sales@sichuanzyyt.com
Products Intro: Product Name:1-Amino-2-methylpropan-2-ol
CAS:2854-16-2
Purity:99%
Company Name: Capot Chemical Co.,Ltd.
Tel: +86-(0)57185586718; +8613336195806
Email: sales@capot.com
Products Intro: Product Name:1-Amino-2-methyl-2-propanol
CAS:2854-16-2
Purity:98% Min. Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: +86-0371-55170693 +86-19937530512
Email: info@tianfuchem.com
Products Intro: Product Name:TIANFU-CHEM 2854-16-2
CAS:2854-16-2
Purity:99% Package:25KG;5KG;1KG

1-Amino-2-methylpropan-2-ol manufacturers

  • 1-Amino-2-methylpropan-2-ol
  • 1-Amino-2-methylpropan-2-ol pictures
  • $0.00 / 100g
  • 2024-07-26
  • CAS:2854-16-2
  • Min. Order: 100g
  • Purity: 97%
  • Supply Ability: 500g 1kg 5kg 10kg 25kg 50kg...
1-Amino-2-methylpropan-2-ol Basic information
Product Name:1-Amino-2-methylpropan-2-ol
Synonyms:1-Amino-2-methylpropan-2-ol;Amino-2-methyl-2-propanol, 1-;1-azanyl-2-methyl-propan-2-ol;1,1-Dimethylethanolamine;2-Amino-a,a-dimethylethanol;2-Hydroxy-2-methyl-1-propylamine;2-Hydroxyisobutylamine;2-Propanol, 1-aMino-2-Methyl-
CAS:2854-16-2
MF:C4H11NO
MW:89.14
EINECS:
Product Categories:pharmacetical
Mol File:2854-16-2.mol
1-Amino-2-methylpropan-2-ol Structure
1-Amino-2-methylpropan-2-ol Chemical Properties
Melting point 8.72°C (estimate)
Boiling point 151°C(lit.)
density 1.915 g/mL at 25 °C
refractive index n20/D1.448
Fp 73℃
storage temp. 2-8°C
solubility Chloroform, Ethyl Acetate (Slightly)
form Oil
pka12.99±0.50(Predicted)
color Clear Colourless
InChIInChI=1S/C4H11NO/c1-4(2,6)3-5/h6H,3,5H2,1-2H3
InChIKeyLXQMHOKEXZETKB-UHFFFAOYSA-N
SMILESC(N)C(C)(O)C
CAS DataBase Reference2854-16-2
NIST Chemistry Reference1-Amino-2-methyl-2-propanol(2854-16-2)
Safety Information
Hazard Codes Xn
Risk Statements 22-37/38-41
Safety Statements 26-39
RIDADR 1993
WGK Germany 3
RTECS UA6125000
HazardClass IRRITANT
PackingGroup 
HS Code 2922190090
MSDS Information
1-Amino-2-methylpropan-2-ol Usage And Synthesis
Chemical PropertiesPale yellow liquid
Uses3-Amino-2-methyl-2-propanol, is a versatile intermediate used for the synthesis of more complex compounds, including inhibitors. It is an intermediate in the preparation of metabolites of Darunavir (D193500), such as (A581405).
Synthesis
Acetone cyanohydrin

75-86-5

1-Amino-2-methylpropan-2-ol

2854-16-2

The general procedure for the synthesis of 1-amino-2-methyl-2-propanol from acetone cyanohydrin is as follows: Step A: Synthesis of 1-amino-2-methyl-2-propanol [Chem.17] To a tetrahydrofuran (180 mL) suspension of lithium aluminum hydride (6.08 g, 160 mmol), a tetrahydrofuran (20 mL) solution of acetone cyanohydrin (7.32 mL, 80.0 mmol) was slowly added dropwise over a controlled period of 15 min at 0 °C. The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with sodium sulfate decahydrate and potassium fluoride. After continued stirring at 35°C for 30 minutes, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give the oily product 1-amino-2-methyl-2-propanol (3.98 g, 56% yield). [0229] 1H-NMR (300 MHz, CDCl3) δ: 2.60 (s, 2H), 1.69 (s, 6H), no peaks for OH and NH2 were observed.

References[1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4336 - 4351
[2] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 50-51
[3] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7319 - 7322
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 18, p. 3347 - 3359
[5] Patent: EP1591446, 2005, A1. Location in patent: Page/Page column 96
Tag:1-Amino-2-methylpropan-2-ol(2854-16-2) Related Product Information
N,N-Dimethyl-1,4-phenylenediamine Glycine Betaine ALTRENOGEST Tiglic aldehyde 2,6-Lutidine Lithium bis(trimethylsilyl)amide 2,6-Dimethylphenol tert-Butanol Amino-2-propanol Tris(hydroxymethyl)aminomethane CYTOCHALASIN E 3,5,5-TRIMETHYLOXAZOLIDINE-2,4-DIONE 1-NITROMETHYLCYCLOHEXANOL ALLOXANTIN DIHYDROCYTOCHALASIN B Cevadine 1-AMINOMETHYL-1-CYCLOHEXANOL HYDROCHLORIDE

  • HomePage | Member Companies | Advertising | Contact us | Previous WebSite | MSDS | CAS Index | CAS DataBase | Privacy | Terms | About Us
  • All products displayed on this website are only for non-medical purposes such as industrial applications or scientific research, and cannot be used for clinical diagnosis or treatment of humans or animals. They are not medicinal or edible.
    According to relevant laws and regulations and the regulations of this website, units or individuals who purchase hazardous materials should obtain valid qualifications and qualification conditions.
  • Copyright © 2023 ChemicalBook All rights reserved.