- 1-Amino-2-methylpropan-2-ol
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- $0.00 / 100g
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2024-07-26
- CAS:2854-16-2
- Min. Order: 100g
- Purity: 97%
- Supply Ability: 500g 1kg 5kg 10kg 25kg 50kg...
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| | 1-Amino-2-methylpropan-2-ol Basic information |
| Product Name: | 1-Amino-2-methylpropan-2-ol | | Synonyms: | 1-Amino-2-methylpropan-2-ol;Amino-2-methyl-2-propanol, 1-;1-azanyl-2-methyl-propan-2-ol;1,1-Dimethylethanolamine;2-Amino-a,a-dimethylethanol;2-Hydroxy-2-methyl-1-propylamine;2-Hydroxyisobutylamine;2-Propanol, 1-aMino-2-Methyl- | | CAS: | 2854-16-2 | | MF: | C4H11NO | | MW: | 89.14 | | EINECS: | | | Product Categories: | pharmacetical | | Mol File: | 2854-16-2.mol |  |
| | 1-Amino-2-methylpropan-2-ol Chemical Properties |
| Melting point | 8.72°C (estimate) | | Boiling point | 151°C(lit.) | | density | 1.915 g/mL at 25 °C | | refractive index | n20/D1.448 | | Fp | 73℃ | | storage temp. | 2-8°C | | solubility | Chloroform, Ethyl Acetate (Slightly) | | form | Oil | | pka | 12.99±0.50(Predicted) | | color | Clear Colourless | | InChI | InChI=1S/C4H11NO/c1-4(2,6)3-5/h6H,3,5H2,1-2H3 | | InChIKey | LXQMHOKEXZETKB-UHFFFAOYSA-N | | SMILES | C(N)C(C)(O)C | | CAS DataBase Reference | 2854-16-2 | | NIST Chemistry Reference | 1-Amino-2-methyl-2-propanol(2854-16-2) |
| Hazard Codes | Xn | | Risk Statements | 22-37/38-41 | | Safety Statements | 26-39 | | RIDADR | 1993 | | WGK Germany | 3 | | RTECS | UA6125000 | | HazardClass | IRRITANT | | PackingGroup | Ⅲ | | HS Code | 2922190090 | | Storage Class | 10 - Combustible liquids | | Hazard Classifications | Acute Tox. 4 Oral
Eye Dam. 1
Skin Irrit. 2
STOT SE 3 |
| | 1-Amino-2-methylpropan-2-ol Usage And Synthesis |
| Chemical Properties | Pale yellow liquid | | Uses | 3-Amino-2-methyl-2-propanol, is a versatile intermediate used for the synthesis of more complex compounds, including inhibitors. It is an intermediate in the preparation of metabolites of Darunavir (D193500), such as (A581405). | | Synthesis | The general procedure for the synthesis of 1-amino-2-methyl-2-propanol from acetone cyanohydrin is as follows:
Step A: Synthesis of 1-amino-2-methyl-2-propanol [Chem.17]
To a tetrahydrofuran (180 mL) suspension of lithium aluminum hydride (6.08 g, 160 mmol), a tetrahydrofuran (20 mL) solution of acetone cyanohydrin (7.32 mL, 80.0 mmol) was slowly added dropwise over a controlled period of 15 min at 0 °C. The reaction mixture was then refluxed for 4 hours. Upon completion of the reaction, the mixture was cooled to 0 °C and the reaction was quenched with sodium sulfate decahydrate and potassium fluoride. After continued stirring at 35°C for 30 minutes, the mixture was filtered through a diatomaceous earth pad. The filtrate was concentrated in vacuum to give the oily product 1-amino-2-methyl-2-propanol (3.98 g, 56% yield).
[0229] 1H-NMR (300 MHz, CDCl3) δ: 2.60 (s, 2H), 1.69 (s, 6H), no peaks for OH and NH2 were observed. | | References | [1] Journal of Medicinal Chemistry, 2012, vol. 55, # 9, p. 4336 - 4351
[2] Patent: WO2010/84767, 2010, A1. Location in patent: Page/Page column 50-51
[3] Tetrahedron Letters, 1996, vol. 37, # 40, p. 7319 - 7322
[4] Journal of Medicinal Chemistry, 1998, vol. 41, # 18, p. 3347 - 3359
[5] Patent: EP1591446, 2005, A1. Location in patent: Page/Page column 96 |
| | 1-Amino-2-methylpropan-2-ol Preparation Products And Raw materials |
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