|
|
| | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Basic information |
| Product Name: | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA | | Synonyms: | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA;1-(2-methylbenzo[d]oxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea;SB-334867 (free base);1-(2-Methylbenzo[d]oxazol-5-yl)-3-(1,5-naphthyridin-4-yl)urea;N-(2-Methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-ylurea SB334867;N-(2-methyl-6-benzoxazolyl)-N'-1,5-naphthyridin-4-yl;1-(2-METHYL-1,3-BENZOXAZOL-6-YL)-3-(1,5-NAPHTHYRIDIN-4-YL)UREA;SB-334867,CID 6604926 | | CAS: | 792173-99-0 | | MF: | C17H13N5O2 | | MW: | 319.32 | | EINECS: | | | Product Categories: | Inhibitors | | Mol File: | 792173-99-0.mol |  |
| | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Chemical Properties |
| Boiling point | 450.5±30.0 °C(Predicted) | | density | 1.472 | | storage temp. | room temp | | solubility | insoluble in H2O; insoluble in EtOH; ≥14.55 mg/mL in DMSO | | form | powder | | pka | 10.21±0.43(Predicted) | | color | white to beige | | CAS DataBase Reference | 792173-99-0 |
| | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Usage And Synthesis |
| Uses | SB 334867 is an orexin 1 receptor antagonist. | | Definition | ChEBI: 1-(2-methyl-1,3-benzoxazol-6-yl)-3-(1,5-naphthyridin-4-yl)urea is a naphthyridine derivative. | | Biological Activity | sb-334867 free base is a selective antagonist of orexin-1 receptor [1].orexin-a and orexin-b are two peptides isolated from rat hypothalamus. they are involved in some physiological functions such as the control of feeding, energy metabolism and regulation of the sleep-wake cycle.sb-334867 free base could inhibit the orexin-a and orexin-b induced calcium responses in cho-ox1 cells with pkb values of 7.27 and 7.23, respectively. sb-334867 was more selective for ox1 receptor over ox2 receptor. it caused 32.7% and 22% inhibition of orexin-a and orexin-b induced calcium responses in cho-ox2 cells, respectively. moreover, sb-334867 was found to reduce both orexin-a-induced and fasting-induced food intake. the acute anorectic effect of it was associated with significant reductions in all active behaviours [1, 2]. | | Biochem/physiol Actions | Lateral hypothalamic orexin neuron activation leads to the development of morphine conditioned place preference, which is preferably blocked by SB-334867. | | storage | Room temperature (desiccate) | | references | [1] smart d, sabido-david c, brough s j, et al. sb-334867-a: the first selective orexin-1 receptor antagonist. british journal of pharmacology, 2001, 132(6): 1179-1182.
[2] rodgers r j, halford j c g, nunes de souza r l, et al. sb-334867, a selective orexin-1 receptor antagonist, enhances behavioural satiety and blocks the hyperphagic effect of orexin-a in rats. european journal of neuroscience, 2001, 13(7): 1444-1452. |
| | N-(2-METHYL-6-BENZOOXAZOLYL)-N''-1,5-NAPHTHYRIDIN-4-YL UREA Preparation Products And Raw materials |
|