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Amitriptyline

Amitriptyline Suppliers list
Company Name: Mainchem Co., Ltd.
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Products Intro: Product Name:Amitriptyline
CAS:50-48-6
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Products Intro: CAS:50-48-6
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:amitriptyline
CAS:50-48-6
Purity:99% Package:5KG;1KG
Company Name: J & K SCIENTIFIC LTD.  
Tel: 400-666-7788 +86-10-82848833
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Products Intro: Product Name:3-(10,11-Dihydro-5H-dibenzo[a,d][7]annulen-5-ylidene)-N,N-dimethyl-1-propanamine
CAS:50-48-6
Package:500mg
Company Name: LGM Pharma  
Tel: 1-(800)-881-8210
Email: inquiries@lgmpharma.com
Products Intro: Product Name:AMitriptyline
CAS:50-48-6
Purity:Typically NLT 98%
Amitriptyline Basic information
Product Name:Amitriptyline
Synonyms:MK-230, N-750, Ro41575;5h-dibenzo(a,d)cycloheptene-delta(5,gamma)-propylamine,10,11-dihydro-n,n-dimet;5H-Dibenzo[a,d]cycloheptene-delta5,gamma-propylamine, 10,11-dihydro-N,N-dimethyl-;Adepress;Adepril;amitriptilina;Amitriptylin;Amitryptiline
CAS:50-48-6
MF:C20H23N
MW:277.4
EINECS:200-041-6
Product Categories:
Mol File:50-48-6.mol
Amitriptyline Structure
Amitriptyline Chemical Properties
Melting point 196-197°C
Boiling point 410.26°C (rough estimate)
density 0.9415 (rough estimate)
refractive index 1.7500 (estimate)
pka9.4(at 25℃)
Water Solubility 9.7 mg/mL
CAS DataBase Reference50-48-6(CAS DataBase Reference)
NIST Chemistry ReferenceAmitriptyline(50-48-6)
EPA Substance Registry System1-Propanamine, 3-(10,11-dihydro-5H-dibenzo[ a,d]cyclohepten-5-ylidene)- N,N-dimethyl-(50-48-6)
Safety Information
HazardClass IRRITANT
Amitriptyline Usage And Synthesis
UsesAntidepressant.
DefinitionChEBI: An organic tricyclic compound that is 10,11-dihydro-5H-dibenzo[a,d][7]annulene substituted by a 3-(dimethylamino)propylidene group at position 5.
Brand nameElavil (AstraZeneca); Endep (Roche);Ami-anelun;Amilent;Amilit-ifi;Aminiurin;Amitimid;Amitriptol;Amyline;Amyzol;Annolytin;Apo-amitriptylline;Apo-pram;Deprelio;Deprestal;Diapatal;Elatrolet;Elavil plus;Emitrip;Enovil;Entrafon-210;Entrafon-2-10;Entrafon-2-25;Entrafon-a;Entrafon-forte;Etarfon;Etrafon-a;Etrafon-forte;Laroxal;Larozyl;Levate;Limbatarail;Limbatral;Limbitryl;Limitrol;Longopax;Loxaryl;Mareline;Meravil;Muaban d;Mutaban a/d/f;Nobrital;Novotriptyn;Novotryptin;Novo-tryptin;Parks-plus;Pms levazine;Prouvil;Saratem;Sarotena;Sedans;Sylvemid;Tensorelax;Teperin;Trepiline;Trepulin;Triptizol;Triptonal;Triptpane;Trivial-4-10.
World Health Organization (WHO)Amitriptyline, a tricyclic antidepressant was introduced in 1961 for the management of endogenous depression and is listed in the 8th WHO Model List of Essential Drugs. Much of the adverse effects are caused by its antimuscarinic actions. These include dry mouth, cardiac arrhythmias, central nervous system disturbances, blood disorders and risk of suicide. The risk of suicide and dangers related to overdosage led the Norwegian Medicines Control Authority to put the higher strength formulation under prescribing restriction in 1992. The risk of death following overdosage is apparently higher for products containing tricyclic compounds as compared with nontricyclic products.
Enzyme inhibitorThis tricyclic antidepressant (FWfree-base = 277.41 g/mol; CAS 50-48-6 (free base) and 549-18-8 (hydrochloride)), marketed under Tryptomer, Elavil, Tryptizol, Laroxyl, Saroten, Sarotex, Lentizol, Endep, and systematically named 3-(10,11-dihydro-5H-dibenzo[a,d]cycloheptene-5-ylidene)-N,Ndimethylpropan- 1-amine, is widely used to treat depressive disorders, anxiety disorders, attention deficit hyperactivity disorder, migraine prophylaxis, eating disorders, bipolar disorder, post-herpetic neuralgia, and insomnia. The pKa = 9.4, and its hydrochloride salt is freely soluble in water. (See Mianserin) Target(s): Ca2+-dependent cyclic nucleotide phosphodiesterase; monoamine oxidase; norepinephrine transporter; serotonin reuptake; K+ channels; Na+ channels, voltage dependent; butyrylcholinesterase, or cholinesterase; glucuronosyltransferase.
Amitriptyline Preparation Products And Raw materials
Preparation ProductsAmitriptyline hydrochloride
Tag:Amitriptyline(50-48-6) Related Product Information
Dimethyl ether Dimethyl fumarate D/L-AMPHETAMINE HYDROCHLORIDE cyproheptadine 10,11-epoxide Cotriptyline Piroheptine AMITRIPTYLINE-D3 HCL (N-METHYL-D3),AMITRIPTYLINE-D3 HYDROCHLORIDE Amitriptyline-d6 HCl,AMITRIPTYLINE-D6 HCL (N,N-DIMETHYL-D6),AMITRIPTYLINE-D6 HYDROCHLORIDE (N,N-DIMETHYL-D6),AMITRIPTYLINE HCL (D6),AMITRIPTYLINE HCL (N,N-DIMETHYL-D6) AMITRIPTYLINE METABOLITE (+-)-(E)-10-HYD ROXYLA,AMITRIPTYLINE METABOLITE (+/-)- amitriptyline N-oxide PIROHEPTINE Amitriptyline N,N-Dimethylformamide PROPANE Dimethyl sulfoxide Dacthal (-)-2-[METHYLAMINO]-1-PHENYLPROPANE Dimethyl carbonate