| Company Name: |
3B Pharmachem (Wuhan) International Co.,Ltd.
|
| Tel: |
821-50328103-801 18930552037 |
| Email: |
3bsc@sina.com |
| Products Intro: |
Product Name:RIBOSTAMYCIN SULFATE SALT
CAS:25546-65-0
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
|
|
| | RIBOSTAMYCIN SULFATE SALT Basic information |
| Product Name: | RIBOSTAMYCIN SULFATE SALT | | Synonyms: | RIBOSTAMYCIN DISULFATE;RIBOSTAMYCIN SULFATE SALT;RIBOSTAMYCIN SULPHATE;antibioticsf733;dekamyciniv;D-Streptamine, O-2,6-diamino-2,6-dideoxy-a-D-glucopyranosyl-(14)-O-[b-D-ribofuranosyl-(15)]-2-deoxy- (8CI, 9CI);NSC 138925;Ribostamycin (base and/or unspecified salts) | | CAS: | 25546-65-0 | | MF: | C17H34N4O10 | | MW: | 454.47 | | EINECS: | 247-091-5 | | Product Categories: | | | Mol File: | 25546-65-0.mol |  |
| | RIBOSTAMYCIN SULFATE SALT Chemical Properties |
| Melting point | 192-195°; mp 175-180° (dec) | | alpha | D23 +42° | | Boiling point | 561.28°C (rough estimate) | | density | 1.1751 (rough estimate) | | refractive index | 1.6700 (estimate) | | storage temp. | 2-8°C | | pka | 7.70(at 25℃) |
| Hazard Codes | T | | Risk Statements | 61-20/21/22 | | Safety Statements | 53-22-36/37/39-45 | | WGK Germany | 3 | | RTECS | WK2300000 | | Toxicity | mouse,LD50,intracrebral,66800ug/kg (66.8mg/kg),BEHAVIORAL: ALTERED SLEEP TIME (INCLUDING CHANGE IN RIGHTING REFLEX)BEHAVIORAL: CONVULSIONS OR EFFECT ON SEIZURE THRESHOLDLUNGS, THORAX, OR RESPIRATION: RESPIRATORY DEPRESSION,Kiso to Rinsho. Clinical Report. Vol. 4, Pg. 2489, 1970. |
| | RIBOSTAMYCIN SULFATE SALT Usage And Synthesis |
| Description | Ribostamycin was found in the culture broth of Streptomyces ribosidificus by Meiji Seika Kaisha in 1970 in the course of screening aminoglycoside antibiotics. It is structurally related to neomycin but lacks the diaminoidose (glucose) moiety substituted on the ribose moiety. Ribostamycin is much less toxic than neomycin and shows strong activity against a variety of gram-positive and gram-negative bacteria, except Pseudomonas aeruginosa. It is used parenterally for therapy of urinary tract, respiratory tract, surgical, and other infections. | | Definition | ChEBI: An amino cyclitol glycoside that is 4,6-diaminocyclohexane-1,2,3-triol having a 2,6-diamino-2,6-dideoxy-alpha-D-glucosyl residue attached at position 1 and a beta-D-ribosyl residue attache
at position 2. It is an antibiotic produced by Streptomyces ribosidificus (formerly S. thermoflavus). | | Mechanism of action | Ribostamycin (SF-733) is produced by
Streptomyces ribosidificus. The free base is crystallized
from methanol solution. The structure
has been determined by chemical methods and
total synthesis has been undertaken . |
| | RIBOSTAMYCIN SULFATE SALT Preparation Products And Raw materials |
|