ChemicalBook > Product Catalog >API >Antipyretic analgesics >Antigout Drugs >Allopurinol

Allopurinol

Allopurinol Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:4-Hydroxy-1H-pyrazolo(3,4-d)pyrimidine
CAS:315-30-0
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Allopurinol
CAS:315-30-0
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:315-30-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
Email: jack.li@time-chemicals.com
Products Intro: Product Name:Allopurinol
CAS:315-30-0
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Allopurinol
CAS:315-30-0

Lastest Price from Allopurinol manufacturers

  • Allopurinol
  • US $1.00 / KG
  • 2019-07-12
  • CAS:315-30-0
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 1ton
  • Allopurinol
  • US $8.00 / kg
  • 2019-07-06
  • CAS:315-30-0
  • Min. Order: 1kg
  • Purity: 99%
  • Supply Ability: 10tons

Related articles

Allopurinol Basic information
Product Name:Allopurinol
Synonyms:Hydroxypyrazolodpyrimidine;pyrazolo(3,4-d)pyrimidin-1-ol;AllopurinolBp2001;4H-Pyrazolo[3,4-d]pyrimidin-4-one, 1,5-dihydro- (7CI,8CI,9CI);ALLOPURINOL, PHARMA;4-Oxopyrazolo[3,4-d]pyrimidine;NSC 101655;ALLOPURINOL,USP
CAS:315-30-0
MF:C5H4N4O
MW:136.11
EINECS:206-250-9
Product Categories:PYRIMIDINE;Miscellaneous Natural Products;Heterocyclic Compounds;Antitumors for Research and Experimental Use;Chemical Reagents for Pharmacology Research;Biochemistry;API's;Miscellaneous Enzyme;Nucleobases and their analogs;Nucleosides, Nucleotides & Related Reagents;Heterocycles;Intermediates & Fine Chemicals;Pharmaceuticals;Fused Ring Systems;-;Bases & Related Reagents;Nucleotides;ZYLOPRIM;inhibitor;Other APIs
Mol File:315-30-0.mol
Allopurinol Structure
Allopurinol Chemical Properties
Melting point >300 °C(lit.)
Boiling point 250.36°C (rough estimate)
density 1.4295 (rough estimate)
refractive index 1.8500 (estimate)
storage temp. Room temperature.
solubility 1 M NaOH: soluble50mg/mL, clear to very slightly hazy, colorless to faintly yellow
form Powder
pka10.2(at 25℃)
color White or almost white
Water Solubility 0.35 g/L (25 ºC)
Merck 14,279
InChIKeyOFCNXPDARWKPPY-UHFFFAOYSA-N
CAS DataBase Reference315-30-0(CAS DataBase Reference)
NIST Chemistry ReferenceAllopurinol(315-30-0)
EPA Substance Registry System4H-Pyrazolo[3,4- d]pyrimidin-4-one, 1,5-dihydro-(315-30-0)
Safety Information
Hazard Codes T,Xi,Xn
Risk Statements 25-43-36/37/38-20/21/22
Safety Statements 28-36/37-45-36/37/39-26-24-36
RIDADR UN 2811 6.1/PG 3
WGK Germany 2
RTECS UR0785000
TSCA Yes
HazardClass 6.1
PackingGroup III
HS Code 29335990
Hazardous Substances Data315-30-0(Hazardous Substances Data)
MSDS Information
ProviderLanguage
1H-Pyrazolo[3,4-d]pyrimidin-4-ol English
ACROS English
SigmaAldrich English
ALFA English
Allopurinol Usage And Synthesis
Chemical PropertiesWhite to Off-White Solid
Usesantihyperuricemia, antigout, antiurolithic
UsesXanthine oxidase inhibitor; decreases uric acid production. Used in treatment of hyperuricemia and chronic gout. Antiurolithic
IndicationsAllopurinol (Zyloprim) is the drug of choice in the treatment of chronic tophaceous gout and is especially useful in patients whose treatment is complicated by renal insufficiency.
Brand nameLopurin (Abbott); Lopurin (BASF); Zyloprim (Promethus).
General DescriptionOdorless tasteless white microcrystalline powder.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileAllopurinol is an aminoalcohol. Amines are chemical bases. They neutralize acids to form salts plus water. These acid-base reactions are exothermic. The amount of heat that is evolved per mole of amine in a neutralization is largely independent of the strength of the amine as a base. Amines may be incompatible with isocyanates, halogenated organics, peroxides, phenols (acidic), epoxides, anhydrides, and acid halides. Flammable gaseous hydrogen is generated by amines in combination with strong reducing agents, such as hydrides. Allopurinol darkens above 572° F, and at an indefinite high temperature, Allopurinol chars and decomposes. At 221° F, maximum stability occurs at pH 3.1- 3.4. Allopurinol decomposes in acidic and basic solutions.
Fire HazardFlash point data for Allopurinol are not available; however, Allopurinol is probably combustible.
Mechanism of actionAllopurinol, in contrast to the uricosuric drugs, reduces serum urate levels through a competitive inhibition of uric acid synthesis rather than by impairing renal urate reabsorption. This action is accomplished by inhibiting xanthine oxidase, the enzyme involved in the metabolism of hypoxanthine and xanthine to uric acid. After enzyme inhibition, the urinary and blood concentrations of uric acid are greatly reduced and there is a simultaneous increase in the excretion of the more soluble uric acid precursors, xanthine and hypoxanthine.
Allopurinol itself is metabolized by xanthine oxidase to form the active metabolite oxypurinol, which tends to accumulate after chronic administration of the parent drug.This phenomenon contributes to the therapeutic effectiveness of allopurinol in long-term use. Oxypurinol is probably responsible for the antigout effects of allopurinol. Oxypurinol itself is not administered because it is not well absorbed orally.
Clinical UseAllopurinol is especially indicated in the treatment of chronic tophaceous gout, since patients receiving it show a pronounced decrease in their serum and urinary uric acid levels. Because it does not depend on renal mechanisms for its efficacy, allopurinol is particularly beneficial for patients who already have developed renal uric acid stones, patients with excessively high urate excretion (e.g., above 1,200 mg in 24 hours), patients with a variety of blood disorders (e.g., leukemia, polycythemia vera), patients with excessive tophus deposition, and patients who fail to respond well to the uricosuric drugs.
Allopurinol also inhibits reperfusion injury. This injury occurs when organs that either have been transplanted or have had their usual blood perfusion blocked are reperfused with blood or an appropriate buffer solution. The cause of this injury is local formation of free radicals, such as the superoxide anion, the hydroxyl free radical, or peroxynitrite. These substances are strong oxidants and are quite damaging to tissues.
Side effectsCommon toxicities associated with allopurinol administration include a variety of skin rashes, gastrointestinal upset, hepatotoxicity, and fever. These reactions are often sufficiently severe to dictate termination of drug therapy. It is advised that therapy not be initiated during an acute attack of gouty arthritis. As with the uricosuric drugs, therapy with allopurinol should be accompanied both by a sufficient increase in fluid intake to ensure water diuresis and by alkalinization of the urine. Prophylactic use of colchicine also helps to prevent acute attacks of gout that may be brought on during the initial period of allopurinol ingestion.
Safety ProfileHuman poison by ingestion. Poison experimentally by intraperitoneal and subcutaneous routes. An experimental teratogen. Human systemic effects by ingestion: blood leukopenia, dermatitis, jaundice, muscle weakness, thrombocytopenia. When heated to decomposition it emits toxic fumes of NOx. An FDA proprietary drug used as a xanthine oxidase inhibitor.
Veterinary Drugs and TreatmentsThe principle veterinary uses for allopurinol are for the prophylactic treatment of recurrent uric acid uroliths and hyperuricosuric calcium oxalate uroliths in small animals. It has also been used in an attempt to treat gout in pet birds and reptiles.
Allopurinol has been recommended as an alternative treatment for canine Leishmaniasis. Although it appears to have clinical efficacy, it does not apparently clear the parasite in most dogs at usual dosages. Allopurinol may also be useful for American Trypanosomiasis.
PrecautionsSince allopurinol is metabolized by the hepatic microsomaldrug-metabolizing enzymes, coadministration ofdrugs also metabolized by this system should be donewith caution. Because allopurinol inhibits the oxidationof mercaptopurine and azathioprine, their individualadministered doses must be decreased by as much as75% when they are given together with allopurinol.Allopurinol may also increase the toxicity of other cytotoxicdrugs (e.g., vidarabine). The actions of allopurinolare not antagonized by the coadministration of salicylates.
Tag:Allopurinol(315-30-0) Related Product Information
5-AMINO-2,6-DIMETHYL-4,5-DIHYDRO-2H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE 6-([2-(4-CHLOROPHENYL)-2-OXOETHYL]SULFANYL)-1-PHENYL-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE 3-(4-OXO-1-PHENYL-4,5-DIHYDRO-1H-PYRAZOLO[3,4-D]PYRIMIDIN-6-YL)PROPANOIC ACID AURORA 19391 ALLOPURINOL RIBOSIDE 6-([2-(4-METHOXYPHENYL)-2-OXOETHYL]SULFANYL)-1-PHENYL-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE 6-[(2-OXO-2-PHENYLETHYL)SULFANYL]-1-PHENYL-1,5-DIHYDRO-4H-PYRAZOLO[3,4-D]PYRIMIDIN-4-ONE BUTTPARK 53\40-91 1,6-DIPHENYLPYRAZOLO[3,4-D][1,3]THIAZOLO[3,2-A]PYRIMIDIN-4(1H)-ONE Allopurinol Fenarimol Zolpidem tartrate Zolpidem 5-Methyl-2-phenyl-1,2-dihydropyrazol-3-one 1-(4-Chlorophenyl)-4,4-dimethyl-3-(1,2,4-triazole-1-yl-methyl)pentane-3-ol 1,5-dihydro-4H-pyrazolo[3,4-d]pyrimidin-4-one, monosodium salt Hexaconazole Pyrimidine