- 3-Indolepropionic acid
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- $0.00 / 25KG
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2023-09-06
- CAS:830-96-6
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 50000KG/month
- 3-Indolepropionic acid
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- $196.00 / 1KG
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2023-06-15
- CAS:830-96-6
- Min. Order: 1KG
- Purity: 98%
- Supply Ability: 1-20mt
- 3-Indolepropionic acid
-
- $0.00 / 1KG
-
2023-01-06
- CAS:830-96-6
- Min. Order: 1KG
- Purity: 98.0%
- Supply Ability: 500kg/month
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| | 3-Indolepropionic acid Basic information |
| | 3-Indolepropionic acid Chemical Properties |
| Melting point | ~133 °C | | Boiling point | 82 °C(lit.) | | density | 0.960 g/mL at 20 °C | | vapor density | 2.1 (vs air) | | vapor pressure | 33 mm Hg ( 20 °C) | | refractive index | n20/D 1.377(lit.) | | Fp | 53 °F | | storage temp. | Sealed in dry,Room Temperature | | solubility | ethanol: soluble50mg/mL, clear, yellow to orange | | pka | 4.77±0.10(Predicted) | | form | crystalline | | color | light yellow | | Water Solubility | slightly soluble | | BRN | 147733 | | CAS DataBase Reference | 830-96-6(CAS DataBase Reference) | | NIST Chemistry Reference | Indole-3-propionic acid(830-96-6) | | EPA Substance Registry System | 1H-Indole-3-propanoic acid (830-96-6) |
| Hazard Codes | Xi | | Risk Statements | 22-36/37/38 | | Safety Statements | 26-37/39 | | WGK Germany | 3 | | RTECS | NM1329000 | | F | 8-10-23 | | TSCA | Yes | | HS Code | 29339990 | | Toxicity | LDLo intraperitoneal in mouse: 100mg/kg |
| | 3-Indolepropionic acid Usage And Synthesis |
| Description | Indole-3-propionic acid is a bacterial metabolite that has antioxidant and neuroprotective activities. It scavenges ABTS radicals in a cell-free assay when used at concentrations ranging from 50 to 150 μM and decreases hydrogen peroxide-induced malondialdehyde (MDA) levels in rat striatal membranes (IC50 = 180 μM). Indole-3-propionic acid also decreases increases in MDA levels induced by amyloid β (1-42) in PC12 cells. It decreases ischemia-induced increases in cell death of pyramidal neurons and levels of 4-hydroxy nonenal (HNE; ) and glial fibrillary acidic protein (GFAP) in the hippocampal CA1 region in gerbils when administered at a dose of 10 mg/kg per day. | | Chemical Properties | pale yellow to yellow crystalline powder | | Uses | Reactant for preparation of:
- Fluorescent analogues of strigolactones
- Anti-tumor agents
- Melanocortin receptors ligands
- Immunosuppressive agents
- Iinhibitors of hepatitis C virus
- Histamine H4 receptor agonists
- NR2B/NMDA receptor antagonists
- CB1 antagonist for the treatment of obesity
- Antibacterial agents
- Inhibitor of TGF-β receptor binding
Indole-3-propionic acid may be used in the synthesis of oxindole-3-propionic acid via reaction with N-bromosuccinimide in acetic acid followed by treatment with H2/Pd catalyst. | | Uses | 3-Indolepropionic acid is a deamination product of Tryptophan (T947200) that protects the hippocampus (studied in gerbils) from ischemic damage and oxidative stress. It’s ability to protect the neurons in this way is attributed to its potent antioxidative effects. 3-Indolepropionic acid is also hypothesized to have protective effects on the thyroid gland. | | Definition | ChEBI: An indol-3-yl carboxylic acid that is propionic acid substituted by a 1H-indol-3-yl group at position 3. | | Synthesis Reference(s) | Tetrahedron Letters, 25, p. 3159, 1984 DOI: 10.1016/S0040-4039(01)90997-9 | | General Description | 3-Indolepropionic acid is an effective inhibitor of aggregation of misfolded β-amyloid protein (Abeta). Three-component one-pot procedure has been reported to assemble 3-indolepropionic acids. | | Biochem/physiol Actions | Studied as an adjunct to improve perfusion after liver transplant. | | Purification Methods | Recrystallise it from EtOH/water [James & Ware J Phys Chem 89 5450 1985]. The picrate has m 143-144o, and the methyl ester crystallises from *C6H6 or MeOH with m 81-83o. [Beilstein 22 III/IV 1113, 22/3 V 114.] |
| | 3-Indolepropionic acid Preparation Products And Raw materials |
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