| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:Mycalolide B
CAS:122752-21-0
Purity:>98% Package:100ug
|
| Company Name: |
Focus Biomolecules
|
| Tel: |
855-362-8721 |
| Email: |
sales@focusbiomolecules.com |
| Products Intro: |
Product Name:Mycalolide B
CAS:122752-21-0
Purity:98% by TLCNMR (Conforms) Package:$235.00/20ug;
|
|
| | MYCALOLIDE B Basic information |
| Product Name: | MYCALOLIDE B | | Synonyms: | MYCALOLIDE B;MYCALOLIDE B, MYCALE SPECIES;Mycalolide B, Mycale sp.;4-O-Acetyl-21-O-de(aminocarbonyl)-23,24-didehydro-39,46-dinor-6-deoxo-25-deoxy-6-(2,3-dimethoxy-1-oxopropoxy)-25-oxokabiramide C;Propanoic acid, 2,3-dimethoxy-, (1R,2S,3R,4R,5E)-3-(acetyloxy)-6-(formylmethylamino)-1-[(3S,4S)-5-[(10S,11R,13E,16S,20S,21R,22S,24E)-16-hydroxy-10,22-dimethoxy-11,21-dimethyl-12,18-dioxo-3,7,19,27-tetraoxa-29,30,31-triazatetracyclo[24.2.1.12,5.16,9]hentriaconta-2(31),4,6(30),8,13,24,26(29),28-octaen... | | CAS: | 122752-21-0 | | MF: | C52H74N4O17 | | MW: | 1027.16 | | EINECS: | | | Product Categories: | | | Mol File: | 122752-21-0.mol |  |
| | MYCALOLIDE B Chemical Properties |
| alpha | -53.4℃ (D) (c=1.3 CHCl3) | | storage temp. | -20°C | | solubility | Soluble in DMSO (up to 20 mg/ml) | | form | Clear to white solid | | color | White | | Stability: | Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
| | MYCALOLIDE B Usage And Synthesis |
| Description | Mycalolide B (122752-21-0) is a novel marine natural product which binds to actin in a 1:1 molar ratio (Kd=13-20 nM).1?It selectively and completely depolymerizes F-actin to G-actin?via?a novel mechanism different from that of the cytochalasin D.2?It is a novel and specific inhibitor of actomyosin ATPase.3 | | References | 1) Saito et al. (1994), Mycalolide B, a novel actin depolymerizing agent; J. Biol. Chem., 269 29710
2) Sugidachi et al. (1998), Inhibition of rat platelet aggregation by mycalolide-B, a novel inhibitor of actin polymerization with a different mechanism of action from cytochalasin-D; Thromb. Haemost., 79 614
3) Hori et al. (1993), Mycalolide-B, a novel and specific inhibitor of actomyosin ATPase isolated from marine sponge; FEBS Lett., 322 151 |
| | MYCALOLIDE B Preparation Products And Raw materials |
|