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| | LATHOSTEROL Basic information |
| | LATHOSTEROL Chemical Properties |
| Melting point | 126°C | | Boiling point | 452.8°C (rough estimate) | | density | 0.9610 (rough estimate) | | refractive index | 1.5250 (estimate) | | storage temp. | -20°C | | solubility | Chloroform (Slightly), Ethyl Acetate (Slightly), Methanol (Slightly, Sonicated) | | form | Solid | | pka | 15.10±0.70(Predicted) | | color | White to Off-White |
| WGK Germany | 3 | | RTECS | FZ7000000 |
| | LATHOSTEROL Usage And Synthesis |
| Uses | A Cholesterol (C432501) metabolite. Lathosterol (indicating cholesterol synthesis) and Sitosterol (indicating cholesterol absorption) also decreased with deteriorating health. Low Lathosterol, Sitosterol (S497050), and Cholesterol (C432501) predicted mortality additively and independently of each other. | | Uses | 5α-Cholest-7-en-3β-ol was used as a substrate in enzymatic assay for plasma cholesterol. It was used to supplement diet of Daphnia galeata to study the effect on life-history traits. | | Uses | Lathosterol has been used as a standard for the estimation of the concentrations of cholesterol and plant sterols. | | Definition | ChEBI: A cholestanoid that is (5alpha)-cholest-7-ene substituted by a beta-hydroxy group at position 3. | | General Description | Lathosterol is a cholesterol synthesis precursor. | | Biochem/physiol Actions | 5α-Cholest-7-en-3β-ol (Lathosterol) is an intermediate in cholesterol biosynthesis pathway. Lathosterol in serum is carried on lipoproteins and is indicative of the rate of cholesterol synthesis. It acts as a marker of synthesis of cholesterol and is not affected by dietary consumption of cholesterol. |
| | LATHOSTEROL Preparation Products And Raw materials |
| Raw materials | Cholest-5-ene-3,7-diol, dibenzoate, (3β,7β)- (9CI)-->7BETA-HYDROXYCHOLESTEROL-->7-oxocholest-5-en-3-beta-yl acetate-->7-Dehydrocholesterol-->Cholesterol-->Ethanol | | Preparation Products | Δ8(14)-Cholestenol-->(3S,5S,10S,13R,14R,17R)-10,13-dimethyl-17-[(2R)-6-methylheptan-2-yl]-2,3,4,5,6,7,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol |
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