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Product Name:A 77636 hydrochloride;(1R-cis)-1-(AMinoMethyl)-3,4-dihydro-3-tricyclo[3.3.1.13,7]dec-1-yl-[1H]-2-benzopyran-5,6-diolhydrochloride
CAS:145307-34-2
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
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EMMX Biotechnology LLC
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Product Name:A 77636 hydrochloride
CAS:145307-34-2
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
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DC Chemicals
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Product Name:A-77636 (hydrochloride)
CAS:145307-34-2
Purity:98% HPLC Package:100mg，250mg，1g
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ChemeGen(Shanghai) Biotechnology Co.,Ltd.
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Product Name:A-77636 hydrochloride
CAS:145307-34-2
Purity:98% Package:10 mg;50 mg;100 mg;500 mg;1 g;5 g;10 g
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| | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE Basic information |
| Product Name: | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE | | Synonyms: | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE;(1R-CIS)-1-(AMINOMETHYL)-3,4-DIHYDRO-3-TRICYCLO[3.3.1.13,7]DEC-1-YL-[1H]-2-BENZOPYRAN-5,6-DIOL HYDROCHLORIDE;A 77636 HYDROCHLORIDE;(1R)-cis-1-Aminomethyl-3,4-dihydro-3-tricyclo[3.3.1.13.7]dec-1-yl-[1-h]-2-benzopyran-5,6-diolhydrochloride;A 77636;(-)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrate hydrochloride;A-77636 hydrate hydrochloride;(?)-(1R,3S)-3-Adamantyl-1-(aminomethyl)-3,4-dihydro-5,6-dihydroxy-1H-2-benzopyran hydrochloride hydrate | | CAS: | 145307-34-2 | | MF: | C20H28ClNO3 | | MW: | 365.89 | | EINECS: | | | Product Categories: | | | Mol File: | 145307-34-2.mol |  |
| | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE Chemical Properties |
| storage temp. | −20°C | | solubility | H2O: 10 mg/mL | | form | solid | | color | off-white | | Water Solubility | Soluble to 100 mM in water |
| | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE Usage And Synthesis |
| Description | A-77636 is a dopamine D1 receptor agonist (Ki = 40 nM). It induces activity equal to or greater than dopamine in an adenylate cyclase assay of D1 receptor activity in fish retina and rat caudate putamen (EC50s = 7.4 and 1.1 nM, respectively) but does not show agonist activity at D2 receptors expressed in MMQ cells when used at concentrations up to 10 μM. A-77636 (10 μM) induces desensitization of dopamine-stimulated cAMP accumulation and downregulation of D1 receptors, reducing D1 receptor expression by 79% in C-6 glioma cells expressing monkey D1A receptors. In a marmoset model of Parkinson''s disease induced by MPTP, A-77636 (3 μmol/kg, s.c.) increases locomotor activity 5.3-fold and reduces disease severity. Subcutaneous administration of A-77636 elicits cortical acetylcholine release at a dose of 1 μmol/kg. It also elicits over a 230% increase in cortical and hippocampal acetylcholine release when administered at a dose of 4 μmol/kg, an effect that is blocked by the D1 antagonist SCH 23390 . | | Uses | The dopamine receptors play important role in cognition, memory, learning, and motor control (1). These receptors have been implicated as a therapeutic target for many psychiatric and neurological disorders. A 77636 Hydrochloride is a selective dopamine D1-like receptor agonist with antiparkinsonian properties (2,3). | | Definition | ChEBI: (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol hydrochloride is a hydrochloride salt obtained by mixing equimolar amounts of (1R,3S)-3-(adamantan-1-yl)-1-(aminomethyl)-3,4-dihydroisochromene-5,6-diol with hydrochloric acid. Potent and selective dopamine D1-like receptor agonist (pEC50 values are 8.97 and < 5 for D1-like and D2-like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo. It has a role as an antiparkinson drug and a dopamine agonist. It contains a (1R,3S)-3-(adamantan-1-yl)-1-(ammoniomethyl)-3,4-dihydroisochromene-5,6-diol(1+). | | Biological Activity | Potent and selective dopamine D 1 -like receptor agonist (pEC 50 values are 8.97 and < 5 for D 1 -like and D 2 -like receptors respectively). Displays anti-Parkinsonian activity following oral administration in vivo . | | storage | Store at -20°C | | references | [1]. kebabian jw, britton dr, deninno mp, et al. a-77636: a potent and selective dopamine d1 receptor agonist with antiparkinsonian activity in marmosets. eur j pharmacol, 1992, 229(2-3): 203-209.
[2]. lin cw, bianchi br, miller tr, et al. persistent activation of the dopamine d1 receptor contributes to prolonged receptor desensitization: studies with a-77636. j pharmacol exp ther, 1996, 276(3): 1022-1029.
[3]. acquas e, day jc, fibiger hc. the potent and selective dopamine d1 receptor agonist a-77636 increases cortical and hippocampal acetylcholine release in the rat. eur j pharmacol, 1994, 260(1): 85-87. |
| | (-)-(1R,3S)-3-ADAMANTYL-1-(AMINOMETHYL)-3,4-DIHYDRO-5,6-DIHYDROXY-1H-2-BENZOPYRAN HYDROCHLORIDE Preparation Products And Raw materials |
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