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EHT1864

EHT1864 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: 21-51619050
Email: ivan@atkchemical.com
Products Intro: Product Name:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
CAS:754240-09-0
Company Name: Hubei xin bonus chemical co. LTD
Tel: 86-13657291602
Email: linda@hubeijusheng.com
Products Intro: Product Name:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
CAS:754240-09-0
Purity:0.99 Package:5KG;1KG
Company Name: career henan chemical co
Tel: +86-0371-86658258
Email: factory@coreychem.com
Products Intro: Product Name: EHT 1864
CAS:754240-09-0
Purity:Min98% HPLC Package:1KG;1USD
Company Name: Dideu Industries Group Limited
Tel: 029-88380327 +8617691182729
Email: Service@dideu.com
Products Intro: Product Name:EHT1864
CAS:754240-09-0
Purity:99.9% Package:25kgs/Drum;200kgs/Drum Remarks:FDA GMP CEP Approved Manufacturer
Company Name: Hefei Hirisun Pharmatech Co., Ltd
Tel: +8615056975894
Email: shawn@hirisunpharm.com
Products Intro: Product Name:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride
CAS:754240-09-0
Purity:0.95 Package:1G;5G;25G;Bulk for inquiry Remarks:HR130797

EHT1864 manufacturers

  • EHT 1864
  • $1.00 / 1KG
  • 2019-12-31
  • CAS:754240-09-0
  • Min. Order: 1KG
  • Purity: Min98% HPLC
  • Supply Ability: g/kg/ton
EHT1864 Basic information
Product Name:EHT1864
Synonyms:5-(5-(7-(Trifluoromethyl)quinolin-4-ylthio)pentyloxy)-2-(morpholinomethyl)-4H-pyran-4-one dihydrochloride;EHT 1864;2-(4-morpholinylmethyl)-5-[[5-[[7-(trifluoromethyl)-4-quinolinyl]thio]pentyl]oxy]-4H-pyran-4-one,hydrochloride (1:2);EHT 1864, >=98%;2-(morpholin-4-ylmethyl)-5-[5-[7-(trifluoromethyl)quinolin-4-yl]sulfanylpentoxy]pyran-4-one,dihydrochloride;CS-1239;CS-1343;EHT-1864;EHT-1864
CAS:754240-09-0
MF:C25H27F3N2O4S2HCl
MW:0
EINECS:
Product Categories:Inhibitors
Mol File:754240-09-0.mol
EHT1864 Structure
EHT1864 Chemical Properties
Melting point >195°C (dec.)
storage temp. 2-8°C
solubility H2O: soluble10mg/mL, clear
form powder
color white to beige
CAS DataBase Reference754240-09-0
Safety Information
WGK Germany 3
MSDS Information
EHT1864 Usage And Synthesis
UsesEHT 1864 is a potent Rac family GTPase inhibitor.
UsesEHT 1864 is an inhibitor of the Rac subfamily of Rho GTPases, that binds to Rac1, Rac1b, Rac2, and Rac3 with Kd values of 40, 50, 50, and 250 nM, respectively. It can reverse transformation of NIH 3T3 fibroblasts caused by constitutively activated Rac1, as well as Rac-dependent transformation caused by Tiam1 or Ras. EHT 1864 inhibits APP processing by γ-secretase, reducing Αβ40 and Αβ42 accumulation. It blocks breast cancer cell invasion in a collagen matrix assay and, at 10 μM, increases the size but decreases the density of dendritic spines of hippocampal neurons in culture.
UsesEHT 1864 has been used to study the regulation of the adapter protein dishevelled-1 ubiquitylation by Rac1 activity.
Biological ActivityInhibitor of Rac family GTPases. Blocks activation by direct binding to Rac1, Rac1b, Rac2 and Rac3 (K D values are 40, 50, 60 and 250 nM respectively). Inhibits Rac, Ras and Tiam-induced growth transformation of NIH-3T3 fibroblasts. Reduces β -amyloid peptide production in vivo .
Biochem/physiol ActionsEHT 1864 inhibits Rac function. It prevents Aβ40 and Aβ42 production in vitro without direct inhibition of g-secretase.
EHT1864 Preparation Products And Raw materials
Tag:EHT1864(754240-09-0) Related Product Information
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