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Oxaliplatin Suppliers list
Company Name: Jiangsu Yew Pharmaceutical Co., Ltd.
Tel: +86-510-66865338 +86-189-2133-5032
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Products Intro: Product Name:Oxaliplatin
Purity:98.5 Package:1KG;40000USD
Company Name: TianYuan Pharmaceutical CO.,LTD
Tel: +86-755-23284190 13684996853
Products Intro: Product Name:Oxaliplatin
Purity:98% Package:10g 100g 200g 500g 1kg 5kg per barrel
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Products Intro: Product Name:Oxaliplatin
Purity:99% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Products Intro: CAS:61825-94-3
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: PI & PI BIOTECH INC.
Tel: 18371201331
Products Intro: Product Name:Oxaliplatin
Purity:90%+ Package:10mg, 25mg, 50mg, 100mg, Other scale please email Remarks:(SP-4-2)-[(1R,2R)-Cyclohexane-1,2-diamine-κN,κN′][ethanedioato(2-)-κO1,κO2]platinum

Lastest Price from Oxaliplatin manufacturers

  • Oxaliplatin
  • US $0.00 / KG
  • 2020-10-27
  • CAS:61825-94-3
  • Min. Order: 100g
  • Purity: 98%+
  • Supply Ability: 100kg
  • Oxaliplatin
  • US $0.00 / g
  • 2020-10-14
  • CAS:61825-94-3
  • Min. Order: 1g
  • Purity: 99%
  • Supply Ability: 5kg
  • Oxaliplatin
  • US $200.00-150.00 / KG
  • 2020-08-25
  • CAS:61825-94-3
  • Min. Order: 1KG
  • Purity: 99.9%
  • Supply Ability: 10tons
Oxaliplatin Basic information
Indications and Usage Mechanisms of Action Adverse Effects
Product Name:Oxaliplatin
Synonyms:[SP-4-2-(1R-TRANS)]-(1,2-CYCLOHEXANEDIAMINE-N,N')[ETHANEDIOATA(2-)-O,O']PLATINUM;OXALIPLATIN;trans-l-diaminocyclohexane oxalatoplatinum;(1,2-cyclohexanediamine-n,n’)(ethanedioato(2-)-o,o’)-platinu(sp-4-2-(1r-tr;1-ohp;oxalato(1r,2r-cyclohexanediammine)platinum(ii);oxalatoplatin;[SP-4-2-(1R-trans)]-(1,2-Cyclohexanediamine-N,N,)[ethanedioato(2-)-O,O’Jplatinum
Product Categories:Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical material and intermeidates;Active Pharmaceutical Ingredients;Antineoplastic;Inhibitors;PRAXILENE;chemical reaction,pharm,electronic,materials;Amines;Heterocycles;APIs
Mol File:61825-94-3.mol
Oxaliplatin Structure
Oxaliplatin Chemical Properties
alpha +74.5-78.0 (D/20)(c=0.5,H2O)
storage temp. Store at +4°C
solubility Slightly soluble in water, very slightly soluble in methanol, practically insoluble in anhydrous ethanol.
form solid
Water Solubility Soluble in water with heating and/or sonication
Merck 14,6912
Stability:Stable. Store cool. Incompatible with oxidizing agents.
CAS DataBase Reference61825-94-3
Safety Information
Hazard Codes Xn,Xi
Risk Statements 36/37/38-40-42/43
Safety Statements 26-36
WGK Germany 3
RTECS TP2275850
HazardClass 6.1(a)
PackingGroup II
HS Code 28439000
ToxicityLD50 intraperitoneal in mouse: 19800ug/kg
MSDS Information
SigmaAldrich English
Oxaliplatin Usage And Synthesis
Indications and UsageOxaliplatin, also called Eloxatin or Eloxatine, is a platinum derivative.
Used clinically to treat patients with metastatic colorectal cancer after failure of fluorouracil treatment, can be used alone or in combination with 5-fluorouracil. It is the third-generation platinum antitumor compound after cisplatin and carboplatin, and so far the only platinum-based drug with significant effectiveness against colorectal cancer. It also inhibits proliferation of ovarian cancer and melanoma cell lines.
Mechanisms of ActionActs on DNA through production of alkylating conjugates, inhibiting its synthesis and reproduction by forming interchain and intrachain cross-links.
Adverse Effects
  • Hematopoietec system: Oxaliplatin has a certain blood toxicity. When used alone, it can cause the following adverse effects: anemia, leukopenia, neutropenia, thrombocytopenia, sometimes reaching grade 3 or 4. Increases hematologic toxicities such as neutropenia and thrombocytopenia when combined with 5-fluorouracil.
  • Digestive system: can cause nausea, vomiting, and diarrhea when used alone. These symptoms can sometimes be very serious. These side effects are significantly exacerbated when used in combination with 5-fluorouacil. Use of prophylactic and/or therapeutic antiemetic drugs is recommended.
  • Nervous system: Peripheral sensory neuropathy characterized by peripheral neuritis. Sometimes associated with convulsions and sensory disturbances in the mouth, upper respiratory tract, and upper GI tract.
DescriptionEloxatin was launched in France for second-line treatment of metastatic colorectal cancer. Oxaliplatin is a second generation platinum drug prepared in three steps from either k2tCl4 or K2Ptl4. It has an antitumor spectrum similar to cisplatin, however, it is more effective against L1210 leukemia and cisplatin resistant L1210. It is also effective against B16 melanoma but has a dose limiting toxicity of peripheral sensory neuropathy that is reversible upon cessation of the drug. The (R,R)- enantiomer has greater activity than the (S,S)-isomer but this is tumor line dependent, e.g., there was no difference found for P-388 or Sarcoma 180. Clinical drug administration based on circadium timing showed it was better tolerated when given 16 h after the onset of light. Oxaliplatin binds to guanineN7 and can lead to bidentate chelation that results in the bending of DNA. This feature is recognized by high mobility group proteins (HMG) which impedes repair reactions and stops replication and transcription.
Chemical PropertiesWhite Crystalline Solid
OriginatorBebiopharm (Switzerland)
UsesThird generation platinum complex. An antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA. Antineoplastic.
UsesA potent anti-neoplastic agent that binds to DNA and shows efficacy in Cisplatin resistant cell lines
UsesOxaliplatin is a platinum-based antineoplastic agent that functions by forming DNA adducts specifically in cancer cells, preventing DNA replication and transcription which leads to cell death. Oxaliplatin has cytotoxic effects in a broad range of cell lines, including colon, ovarian, and lung cancer, with IC50 values ranging from 0.5-240, 0.12-19.8, and 2.6-6.1 μM, respectively. Through its general cytotoxic effects, oxaliplatin has anti-tumor activity against advanced colorectal cancer and is typically administered with fluorouracil and leucovorin in a combination known as FOLFOX.
UsesA antitumor agent with activity against colorectal cancer. Cytotoxicity follows the formation of adducts with DNA
Brand nameEloxatin (Sanofi Aventis).
General DescriptionOxaliplatin is available in 50- and 100-mg vials for IV administrationin the treatment of ovarian cancer, metastaticcolorectal cancer, and early stage colon cancer in combinationwith 5-fluorouracil/leucovorin. The activation of theagent occurs in low-chloride environments to give theaquated species, which subsequently reacts with DNA in amanner similar to cisplatin. The mechanisms of resistance aresimilar for the two agents; however, oxaliplatin is not recognizedby MMR enzymes and does not show cross-resistancewith cisplatin. The agent is widely distributed, highly proteinbound (85%–88%), and irreversibly binds to erythrocytes.Numerous metabolites have been identified many of whichare produced as a result of nonenzymatic processes and includechloro-, dichloro-, monoaquo-, and diaquo-species.The parent and metabolites are eliminated primarily in theurine with a long terminal elimination half-life of 240 hours.Neurotoxicity is dose limiting and normally presents as peripheralneuropathy, which may be exacerbated by exposureto low temperatures. The neurotoxicity is normally reversiblein contrast to that seen with cisplatin, which may be irreversible.Other adverse effects include nausea, vomiting, diarrhea,myelosuppression, and hypersensitivity reactions.Ototoxicity and renal toxicity occur only rarely in contrast tocisplatin.
Biological ActivityAntitumor agent that forms platinum-DNA adducts. Causes intra- and interstrand DNA crosslinks blocking DNA replication and transcription. Displays higher cytotoxicity and lower nephrotoxicity than analog cisplatin (cis-Diaminodichloroplatinum ) and shows antitumor activity in cell lines with acquired cisplatin resistance.
Safety ProfileA poison by intraperitoneal route. When heated to decomposition it emits toxic vapors of NOx and Pt.
Oxaliplatin Preparation Products And Raw materials
Raw materialsSilver nitrate-->Dipotassium rabdosiin Rabdosiin-->1,2-Diaminocyclohexane
Tag:Oxaliplatin(61825-94-3) Related Product Information
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