α-MSH (11-13) (free acid) manufacturers
- KPV
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- $50.00 / 1box
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2024-04-08
- CAS:67727-97-3
- Min. Order: 1box
- Purity: >99%
- Supply Ability: 20tons
- KPV
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- $10.00 / 1kg
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2024-04-02
- CAS:67727-97-3
- Min. Order: 1kg
- Purity: 99%
- Supply Ability: 100 tons
- KPV
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- $10.00 / 1mg
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2024-03-08
- CAS:67727-97-3
- Min. Order: 1mg
- Purity: 99%
- Supply Ability: 1000g
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| | α-MSH (11-13) (free acid) Basic information |
| Product Name: | α-MSH (11-13) (free acid) | | Synonyms: | α-Melanotropin(11-13);α-Melanotropin(11-13)[human];α-Melanotropin(11-13)[pig];α-MSH(11-13)[human];α-MSH(11-13)[pig];a-MSH (11-13) (free acid);H-LYS-PRO-VAL-OH ACETATE SALT;H-LYS-PRO-VAL-OH ACOH | | CAS: | 67727-97-3 | | MF: | C16H30N4O4 | | MW: | 342.43 | | EINECS: | | | Product Categories: | | | Mol File: | 67727-97-3.mol |  |
| | α-MSH (11-13) (free acid) Chemical Properties |
| storage temp. | -15°C | | InChI | InChI=1S/C16H30N4O4/c1-10(2)13(16(23)24)19-14(21)12-7-5-9-20(12)15(22)11(18)6-3-4-8-17/h10-13H,3-9,17-18H2,1-2H3,(H,19,21)(H,23,24)/t11-,12-,13-/m0/s1 | | InChIKey | YSPZCHGIWAQVKQ-AVGNSLFASA-N | | SMILES | C(O)(=O)[C@H](C(C)C)NC(=O)[C@@H]1CCCN1C(=O)[C@H](CCCCN)N |
| | α-MSH (11-13) (free acid) Usage And Synthesis |
| Definition | ChEBI: Lys-Pro-Val is an oligopeptide. | | Biological Activity | The C-terminal tripeptide α-MSH(11–13), also known as KPV (L-Lys-L-Pro-L-Val), exhibited anti-inflammation without induction of cutaneous pigmentation in a frog skin bioassay. The underlying molecular mechanisms of the α-MSH(11–13) anti-inflammatory properties have not been determined in detail. However, they are related to an inhibition of TNF-α, IL-6, and nitric oxide production in a model of LPS-stimulated murine microglial cell culture[1]. Furthermore, it has been recently shown that α-MSH(11–13) reduces activation of NF-κB and decreases its translocation into the nucleus by interaction with importin family proteins.
| | References | [1] Eva-Verena Schaible. “Single administration of tripeptide α-MSH(11-13) attenuates brain damage by reduced inflammation and apoptosis after experimental traumatic brain injury in mice.” PLoS ONE (2013): e71056. |
| | α-MSH (11-13) (free acid) Preparation Products And Raw materials |
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