| Company Name: |
J & K SCIENTIFIC LTD.
|
| Tel: |
010-82848833 400-666-7788 |
| Email: |
jkinfo@jkchemical.com |
| Products Intro: |
Product Name:(E)-3-(2,3,4,5-TetrabroMophenyl)acrylic Acid
CAS:934358-00-6
Package:100Mg,10Mg
|
| Company Name: |
VDM Biochemicals
|
| Tel: |
0330-2528181 |
| Email: |
sales@vdmbio.com |
| Products Intro: |
Product Name:Casein Kinase II Inhibitor III
CAS:934358-00-6
Purity:>=95% by HPLC Package:95USD/5mg
|
|
| | Casein Kinase II Inhibitor III Basic information |
| Product Name: | Casein Kinase II Inhibitor III | | Synonyms: | InSolution? Casein Kinase II Inhibitor III, TBCA;Casein Kinase II Inhibitor III;(E)-3-(2,3,4,5-Tetrabromophenyl)acrylic Acid;TBCA;Tetrabromocinnamic acid;Casein Kinase II Inhibitor III, TBCA;SVJQCVOKYJWUBC-OWOJBTEDSA-N;(2E)-3-(2,3,4,5-Tetrabromophenyl)-2-propenoic acid | | CAS: | 934358-00-6 | | MF: | C9H4Br4O2 | | MW: | 463.74 | | EINECS: | | | Product Categories: | Apoptosis Inducers | | Mol File: | 934358-00-6.mol |  |
| | Casein Kinase II Inhibitor III Chemical Properties |
| Melting point | 189.2-191.2 °C | | Boiling point | 490.8±45.0 °C(Predicted) | | density | 2.443±0.06 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: soluble20mg/mL, clear | | pka | 3.83±0.16(Predicted) | | form | powder | | color | white to beige |
| | Casein Kinase II Inhibitor III Usage And Synthesis |
| Uses | Casein Kinase II Inhibitor III is a casein kinase 2 inhibitor. A protein kinase inhibitors used to elucidate cellular signaling pathways. | | Biological Activity | tetrabromocinnamic acid (tbca) is a new class of specific protein kinase ck2 inhibitors [1].protein kinases have been involved in catalyzing the phosphorylation of serine, threonine and tyrosine residues in protein substrates that play dominant roles in controlling nearly all cellular functions. the ser/thr-specific protein kinase ck2 has been implicated in signal transduction, gene expression, dna repair, rna and protein synthesis. ck2 is invariably elevated in a wide spectrum of tumours [1]. | | in vitro | tbca was a selective, cell-permeable inhibitor of ck2 with an ic50 of 0.11 μm. the ki value was 77 nm. tbca showed minimal effect on a panel of 28 other kinases. tbca induced cell death in jurkat adult t cell leukemia cells with an dc50 of 7.7 μm [1]. tbca dose-dependently inhibited platelet aggregation and secretion induced by various agonists including 2-mesadp, aypgkf, sfllrn, and crp [2]. tbca also significantly inhibited agonist-induced thromboxane a2 (txa2) generation and erk phosphorylation. tbca significantly inhibited platelet spreading on immobilized fibrinogen surface and clot retraction mediated by integrin αiibβ3 signaling [2]. | | storage | Store at +4°C | | references | [1] pagano m a, poletto g, di maira g, et al. tetrabromocinnamic acid (tbca) and related compounds represent a new class of specific protein kinase ck2 inhibitors[j]. chembiochem, 2007, 8(1): 129-139.
[2] ryu s y, kim s. evaluation of ck2 inhibitor (e)-3-(2, 3, 4, 5-tetrabromophenyl) acrylic acid (tbca) in regulation of platelet function[j]. european journal of pharmacology, 2013, 720(1): 391-400. |
| | Casein Kinase II Inhibitor III Preparation Products And Raw materials |
|