124447-81-0
| 中文名称 | 124447-81-0 |
|---|---|
| 中文同义词 | RAT AMYLIN;胰淀素受体AMYLIN, AMIDE, RAT;胰淀素(大鼠) |
| 英文名称 | Amylin (mouse, rat) |
| 英文同义词 | Amylin (mouse, rat);AMylin (Mouse, rat) IAPP (Mouse, rat), Islet aMyloid polypeptide (Mouse, rat);H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2;IAPP (Mouse, rat), Islet aMyloid polypeptide (Mouse, rat);Amylin (mouse, rat) trifluoroacetate salt H-Lys-Cys-Asn-Thr-Ala-Thr-Cys-Ala-Thr-Gln-Arg-Leu-Ala-Asn-Phe-Leu-Val-Arg-Ser-Ser-Asn-Asn-Leu-Gly-Pro-Val-Leu-Pro-Pro-Thr-Asn-Val-Gly-Ser-Asn-Thr-Tyr-NH2 trifluoroacetate salt (Disulfide bond);Ratamylin;Amylin, amide, rat acetate |
| CAS号 | 124447-81-0 |
| 分子式 | C167H272N52O53S2 |
| 分子量 | 3920.39318 |
| EINECS号 | |
| 相关类别 | |
| Mol文件 | 124447-81-0.mol |
| 结构式 |  |
124447-81-0 性质
Amylin receptor AMY1 and AMY3
Amylin is an important, but poorly understood, 37 amino acid glucoregulatory hormone with great potential to target metabolic diseases. Amylin is a member of the calcitonin (CT) family of peptides, which includes CT itself, the CGRPs comprising two variants (αCGRP and βCGRP), adrenomedullin (AM) and AM2 (intermedin). Amylin is a centrally acting, neuroendocrine hormone synthesized with insulin in the beta cells of pancreatic islets. Amylin regulates glucose homeostasis by inhibiting gastric emptying, inhibiting the release of the counter-regulatory hormone glucagon and inducing meal-ending satiety. Amylin functions as a glucoregulatory and satiety-inducing hormone, which is protective against postprandial spikes in blood glucose and overeating.