ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR
| 中文名称 | ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR |
|---|---|
| 中文同义词 | GLUCAGON (19-29) (人);胰岛素分泌抑制剂;胰高血糖素GLUCAGON (19-29) (HUMAN, RAT, PORCINE);胰高血糖素(19-29)(人类),三氟乙酸盐 |
| 英文名称 | H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH |
| 英文同义词 | AQDFVQWLMNT;H-ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR-OH;GLUCAGON (19-29), BOVINE, HUMAN, PORCINE;GLUCAGON (19-29), HUMAN;GLUCAGON (19-29) (HUMAN, BOVINE, PORCINE);ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR;glucagon(19-29;PHE-VAL-GLN-TRP-LEU-MET-ASN-THR: FVQWLMNT |
| CAS号 | 64790-15-4 |
| 分子式 | C61H89N15O18S |
| 分子量 | 1352.51 |
| EINECS号 | |
| 相关类别 | 多肽;标准品;目录多肽;Peptide;Obesity |
| Mol文件 | 64790-15-4.mol |
| 结构式 |  |
ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR 性质
| 沸点 | 1828.5±65.0 °C(Predicted) |
|---|---|
| 密度 | 1.339±0.06 g/cm3(Predicted) |
| 储存条件 | -15°C |
| 溶解度 | 不溶于乙醇；不溶于水； DMSO 中≥135.2 mg/mL |
| 酸度系数(pKa) | 3.19±0.10(Predicted) |
| 形态 | 粉末 |
Insulin secretion
Glucagon (19-29), from 0.1 pM to 1 nM, exerts a potent negative inotropic action. The most striking observation is a 45% increase in the amplitude of cell contractility elicited by the combination of 30 nM glucagon with 1 nM Glucagon (19-29).
Glucagon (19-29), also named Miniglucagon, is the COOH-terminal (19-29) fragment processed from glucagon. Glucagon (19-29) dose-dependently inhibits insulin secretion stimulated by 8.3 M glucose, with no change in the perfusion flow rate. A concentration of 1 nM Glucagon (19-29) has a significant inhibitory effect on a 1 nM glucagon-like peptide 1 (7-36) amide–potentiated insulin secretion. Glucagon (19-29) is a highly potent and efficient inhibitor of insulin release by closing, via hyperpolarization, voltage-dependent Ca 2+ channels linked to a pathway involving a pertussis toxin-sensitive G protein.
安全信息
| 更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
|---|---|---|---|---|---|
| 2024/04/30 | HY-P0150 | ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR Glucagon (19-29), human | 64790-15-4 | 5mg | 420元 |
| 2024/04/30 | HY-P0150 | ALA-GLN-ASP-PHE-VAL-GLN-TRP-LEU-MET-ASN-THR Glucagon (19-29), human | 64790-15-4 | 10mg | 600元 |