- Pantoprazole sulfide
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- $35.00 / 1KG
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2021-11-23
- CAS:102625-64-9
- Min. Order: 500KG
- Purity: ≥98%
- Supply Ability: 100tons
- Pantoprazole Sulfide
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- $15.00 / 1KG
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2021-07-13
- CAS:102625-64-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
- Pantoprazole Sulfide
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- $15.00 / 1KG
-
2021-07-10
- CAS:102625-64-9
- Min. Order: 1KG
- Purity: 99%+ HPLC
- Supply Ability: Monthly supply of 1 ton
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| | 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Basic information |
| | 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Chemical Properties |
| Melting point | 110-118°C | | Boiling point | 526.3±60.0 °C(Predicted) | | density | 1.43±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,2-8°C | | solubility | DMSO (Slightly), Methanol (Slightly) | | pka | 8.97±0.10(Predicted) | | color | Off-White to Light Brown | | BRN | 5358607 | | Major Application | pharmaceutical | | InChI | InChI=1S/C16H15F2N3O3S/c1-22-13-5-6-19-12(14(13)23-2)8-25-16-20-10-4-3-9(24-15(17)18)7-11(10)21-16/h3-7,15H,8H2,1-2H3,(H,20,21) | | InChIKey | UKILEIRWOYBGEJ-UHFFFAOYSA-N | | SMILES | C1(SCC2=NC=CC(OC)=C2OC)NC2=CC(OC(F)F)=CC=C2N=1 | | CAS DataBase Reference | 102625-64-9(CAS DataBase Reference) |
| WGK Germany | WGK 3 | | HS Code | 2933399090 | | Storage Class | 11 - Combustible Solids |
| | 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Usage And Synthesis |
| Chemical Properties | Beige Solid | | Uses | Pantoprazole Sulfide (Pantoprazole EP Impurity B) is a metabolite of Pantoprazole (P183000), an antiulcerative, gastric pump inhibitor. | | Uses | A metabolite of Pantoprazole, an antiulcerative, gastric pump inhibitor | | Synthesis | [Example 1] Preparation of 5-(difluoromethoxy)-2-(((3,4-dimethoxypyridin-2-yl)methyl)thio)-1H-benzo[d]imidazole: 920 mL of isopropanol, 92.1 g of 5-difluoromethoxy-2-mercapto-1H-benzimidazole, and 95.8 g of 2-chloromethyl-3,4-dimethoxypyridine were added to the reactor. Sodium hydroxide solution (prepared by dissolving 20.5 g of sodium hydroxide in 920 mL of pure water) was added slowly and dropwise to the above mixture, followed by stirring the reaction mixture for 2 hours at room temperature. Upon completion of the reaction, 920 mL of pure water was added to the mixture and stirring was continued for 1 hour. The resulting solid product was collected by filtration and dried under vacuum to give 137.4 g of the target compound in 87.8% yield with a melting point of 94 °C. | | References | [1] Patent: WO2009/75516, 2009, A2. Location in patent: Page/Page column 4
[2] Organic Process Research and Development, 2013, vol. 17, # 10, p. 1272 - 1276 |
| | 5-Difluoromethoxy-2-{[(3,4-dimethoxy-2-pyridinyl)methyl]thio}-1H-benzimidazole Preparation Products And Raw materials |
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