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| | A 286982 Basic information |
| Product Name: | A 286982 | | Synonyms: | A 286982;(2E)-1-(4-Acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-2-propen-1-one;2-Propen-1-one, 1-(4-acetyl-1-piperazinyl)-3-[4-[[2-(1-methylethyl)phenyl]thio]-3-nitrophenyl]-, (2E)-;A 286982,Integrin,allosteric,LFA-1,A286982,Inhibitor,A-286982,inhibit,ICAM-1 | | CAS: | 280749-17-9 | | MF: | C24H27N3O4S | | MW: | 453.55 | | EINECS: | | | Product Categories: | | | Mol File: | 280749-17-9.mol |  |
| | A 286982 Chemical Properties |
| storage temp. | -20°C | | solubility | DMSO: soluble10mg/mL, clear | | form | powder | | color | white to beige |
| | A 286982 Usage And Synthesis |
| Description | A286982 is an inhibitor that blocks the integrin-ligand interaction between leukocyte function-associated antigen-1 (LFA-1) and intercellular adhesion molecule-1 (ICAM-1; IC50 = 35 nM). It inhibits adhesion of JY-8 cells to ICAM-1-coated microtiter plates (IC50 = 44 nM). | | Uses | A 286982 is a potent lymphocyte function-associated antigen-1 (LFA-1) and intracellular adhesion mol.-1 (ICAM-1) interaction inhibitor. | | storage | Store at RT | | references | [1]. liu, g., et al., discovery of novel p-arylthio cinnamides as antagonists of leukocyte function-associated antigen-1/intracellular adhesion molecule-1 interaction. 1. identification of an additional binding pocket based on an anilino diaryl sulfide lead. j med chem, 2000. 43(21): p. 4025-40.
[2]. katakai, t., k. habiro, and t. kinashi, dendritic cells regulate high-speed interstitial t cell migration in the lymph node via lfa-1/icam-1. j immunol, 2013. 191(3): p. 1188-99.
[3]. keating, s.m., et al., competition between intercellular adhesion molecule-1 and a small-molecule antagonist for a common binding site on the alphal subunit of lymphocyte function-associated antigen-1. protein sci, 2006. 15(2): p. 290-303. |
| | A 286982 Preparation Products And Raw materials |
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