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| | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Basic information |
| Product Name: | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- | | Synonyms: | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-;(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl);(R)-5-(2,2-Dimethyl-4H-1,3-benzodioxin-6-yl)-1,3-oxazolidin-2-one;BNKY020-VT04;Vilanterol Impurity 29;Vilanterol internate 1;(5R)-2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-y...;TIANFU CHEM 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- | | CAS: | 452339-73-0 | | MF: | C13H15NO4 | | MW: | 249.26 | | EINECS: | 1592732-453-0 | | Product Categories: | 452339-73-0;Intermediate | | Mol File: | 452339-73-0.mol |  |
| | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Chemical Properties |
| Melting point | 160 - 163°C | | Boiling point | 489.6±45.0 °C(Predicted) | | density | 1.223±0.06 g/cm3(Predicted) | | storage temp. | Inert atmosphere,Store in freezer, under -20°C | | solubility | Chloroform (Sparingly), Methanol (Slightly) | | pka | 12.29±0.40(Predicted) | | form | Solid | | color | White to Off-White |
| | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Usage And Synthesis |
| Uses |
(5R)-5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-2-Oxazolidinone (2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)-) is a reagent applied in the preparation of alkyl-linked di-phenyl aminoalcohols as long-acting β2 adrenergic receptor agonist. It is used as an antedrug.
| | Synthesis |
(R)-2-amino-1-(2,2-dimethyl-4H-benzo[d][1,3]dioxin-6-yl)ethan-1-ol (29.8g, 134.0mmol, 1.0eq.) and tetrahydrofuran (300mL) were added to the reaction flask under nitrogen protection, the reaction solution was heated to 40-60°C, and N, N'- Carbonyldiimidazole (22.7 g, 140.0 mmol, 1.05 eq.).After the addition, the reaction solution was kept at a temperature of 40-60° C. and stirred until the raw material reaction was completed. After the reaction, the solution was cooled to 15-30° C., and water (400 mL) was added. Then, the mixture was continuously cooled to 0-10°C and kept stirring. The precipitated solid was filtered, and the filter cake was washed with water. The filter cake was collected and dried under reduced pressure to obtain 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- (30 g, 120.4 mmol, 89.9% yield).
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| | 2-Oxazolidinone, 5-(2,2-diMethyl-4H-1,3-benzodioxin-6-yl)-, (5R)- Preparation Products And Raw materials |
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