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| N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Basic information |
Product Name: | N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine | Synonyms: | TR 14035;(S)-2-(2,6-DichlorobenzaMido)-3-(2',6'-diMethoxy-[1,1'-biphenyl]-4-yl)propanoic acid;N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine;(alphaS)-alpha-[(2,6-Dichlorobenzoyl)amino]-2',6'-dimethoxy-[1,1'-biphenyl]-4-propanoic acid;MDK1191;MDK-1191;TR 14035;TR14035;MDK-1191;MDK1191;TR-14035;TR 14035;TR14035 | CAS: | 232271-19-1 | MF: | C24H21Cl2NO5 | MW: | 474.33 | EINECS: | | Product Categories: | | Mol File: | 232271-19-1.mol | |
| N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Chemical Properties |
Boiling point | 604.0±55.0 °C(Predicted) | density | 1.333 | storage temp. | 2-8°C | solubility | DMSO: ≥ 41 mg/mL (86.44 mM) | form | Powder | pka | 3.53±0.10(Predicted) | color | White to off-white |
| N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Usage And Synthesis |
Biological Activity | TR-14035 (SB 683698, MDK-1191) is a dual alpha4beta (α4β) integrin antagonist with IC50 values of 7 nM and 87 nM for alpha4beta7 (α4β7) and alpha4beta1 (α4β1), respectively. | in vitro | TR-14035 blocks adhesion of RPMI-8866 cells to MAdCAM-Ig by 100% at 1 μM, with an approximate IC 50 of 0.01 μM. | target | Target | Value | α4β7 (Cell-free assay) | 7 nM | α4β1 (Cell-free assay) | 87 nM |
| storage | Store at -20°C |
| N-(2,6-Dichlorobenzoyl)-4-(2,6-diMethoxyphenyl)-L-phenylalanine Preparation Products And Raw materials |
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