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4-Hydroxytolbutamide

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Company Name: Changzhou Ansciep Chemical Co., Ltd.
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Products Intro: Product Name:4-Hydroxytolbutamide
CAS:5719-85-7
Purity:98% Package:100g, 500g, 1kg, 25kg, 50kg, 200kg Remarks:Good quality; Large stock; Hot sale
Company Name: Hubei Jusheng Technology Co.,Ltd.
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Products Intro: Product Name:4-hydroxytolbutamide
CAS:5719-85-7
Purity:0.99 Package:5KG;1KG Remarks:C12H18N2O4S
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Products Intro: Product Name:4-Hydroxytolbutamide；Hydroxytolbutamide
CAS:5719-85-7
Purity:98.00% Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
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Products Intro: Product Name:4-Hydroxytolbutamide
CAS:5719-85-7
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Products Intro: Product Name:4-Hydroxytolbutamide
CAS:5719-85-7
Purity:0 Package:1g; 5g; 25g; 1kg; 5kg; 25kg Remarks:0
4-Hydroxytolbutamide Basic information
Product Name:4-Hydroxytolbutamide
Synonyms:4-HYDROXYTOLBUTAMIDE;HYDROXY TOLBUTAMIDE;N-(BUTYLAMINOCARBONYL)-4-HYDROXYMETHYLBENZENESULFONAMIDE;N-(Butylamnocarbonyl)-4-hydroxymethylbenzenesulfonamide;hydroxymethyltolbutamide;4-Hydroxytolbutamide,N-(Butylaminocarbonyl)-4-hydroxymethylbenzenesulfonamide;1-Butyl-3-(p-hydroxyMethylphenyl)sulfonylurea;HydroxyMethylcarbutaMide
CAS:5719-85-7
MF:C12H18N2O4S
MW:286.35
EINECS:200-835-2
Product Categories:Various Metabolites and Impurities;Metabolites;Metabolites & Impurities
Mol File:5719-85-7.mol
4-Hydroxytolbutamide Structure
4-Hydroxytolbutamide Chemical Properties
Melting point 100-102 °C
density 1.268±0.06 g/cm3(Predicted)
Fp 2℃
storage temp. 2-8°C
solubility ethanol: 12 mg/mL
form Solid
pka4.96±0.10(Predicted)
color white
Safety Information
Hazard Codes F,Xn
Risk Statements 11-20/21/22-36
Safety Statements 16-36/37-24/25
RIDADR UN 1648 3 / PGII
WGK Germany 3
HS Code 29350090
MSDS Information
ProviderLanguage
SigmaAldrich English
4-Hydroxytolbutamide Usage And Synthesis
Description4-hydroxy Tolbutamide is a cytochrome P450 2C8 (CYP2C8) and CYP2C9 metabolite of tolbutamide, a first-generation potassium channel blocker. Tolbutamide 4-hydroxylation is an often used probe reaction in the pharmaceutical industry for the characterization of CYP2C8 and CYP2C9 involvement in the metabolism of clinical drugs.
Chemical PropertiesWhite Solid
Uses4-Hydroxytolbutamide has been used as a standard to assay the fungal biotransformation of tolbutamide to 4′-hydroxytolbutamide.
UsesA metabolite of Tolbutamide. Formed by the cytochrome CYP2CIIC8 and IIC9 subfamily of P450 enzymes
DefinitionChEBI: A urea that consists of 1-butylurea having a 4-hydroxymethylbenzenesulfonyl group attached at the 3-position.
4-Hydroxytolbutamide Preparation Products And Raw materials
Tag:4-Hydroxytolbutamide(5719-85-7) Related Product Information
3-Aminobenzenesulfonamide Sulfanilamide Tosyl chloride Benzenesulfonamide N-n-Butyl benzene sulfonamide Butylated Hydroxytoluene p-Toluenesulfonamide Tris(hydroxymethyl)aminomethane Tosyl cyanide TOLBUTAMIDE Tolbutamide-d9 TOLAZAMIDE 4-Carboxytolbutamide Methyl Ester Tolbutamide 4-Carboxy Ethyl Ester Tolbutamide Impurity 5 L-ACYLASE CARBOXYTOLBUTAMIDE-D9 (BUTYL-D9) CARBOXYTOLBUTAMIDE