D-鞘氨醇
| 中文名称 | D-鞘氨醇 |
|---|---|
| 中文同义词 | D-神经鞘氨醇(牛);D-鞘氨醇;D-神经鞘氨醇;D-赤型神经胺;神經胺醇;D-赤-鞘氨醇;(2S,3R,4E)-2-氨基-4-十八碳烯-1,3-二醇;D-赤式-鞘氨醇 |
| 英文名称 | D-ERYTHRO-SPHINGOSINE |
| 英文同义词 | SPHINGOSINE, C18 CHAIN;TRANS D-THREO-SPHINGOSINE;TRANS D-ERYTHRO-SPHINGOSINE;TRANS-D-ERYTHRO-2-AMINO-4-OCTADECENE-1,3-DIOL;BRAIN SPHINGOSINE;BRAIN, BOVINE;EGG SPHINGOSINE;D-SPHINGOSINE (BOVINE) |
| CAS号 | 123-78-4 |
| 分子式 | C18H37NO2 |
| 分子量 | 299.49 |
| EINECS号 | 204-651-3 |
| 相关类别 | 原料药;其他科研原料药;脂类;抗体-二抗;常用糖合成中间体;糖脂;Amines;Protein Kinase;Mixed Fatty Acids;Fatty Acid Derivatives & Lipids;Glycerols;Inhibitors;Protein Kinase Inhibitors and Activators |
| Mol文件 | 123-78-4.mol |
| 结构式 |  |
D-鞘氨醇 性质
| 熔点 | 74.2-78.1 °C |
|---|---|
| 沸点 | 440.8°C (rough estimate) |
| 密度 | 0.9758 (rough estimate) |
| 折射率 | 1.5000 (estimate) |
| 储存条件 | -20°C |
| 溶解度 | 氯仿：20 mg/mL，澄清，无色至微黄色 |
| 酸度系数(pKa) | 11.80±0.45(Predicted) |
| 形态 | 粉末或蜡状固体 |
| 颜色 | 白色至奶油色 |
| Merck | 14,8747 |
| BRN | 1727294 |
| 稳定性 | 稳定的。与强酸、强碱、强氧化剂不相容。 |
| InChIKey | WWUZIQQURGPMPG-KRWOKUGFSA-N |
| CAS 数据库 | 123-78-4 |
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p32 8 μM (EC 50 ) |
PKC
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PP2A
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Human Endogenous Metabolite
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A p32-sphingosine-activated protein kinase responds to low concentrations of D-erythro-Sphingosine with an initial activation observed at 2.5 μM and a peak activity at 10-20 μM. This kinase shows a modest specificity for D-erythro-Sphingosine over other sphingosine tereoisomers, and a preference for sphingosines over ihydrosphingosines. D-erythro-Sphingosine inhibits protein kinase C in vitro. D-erythro-Sphingosine has been shown to inhibit protein kinase C, which affects cell regulation and several signal transduction pathways, and exhibits antitumor promoter activities in various mammalian cells.
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