- CX6258
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- $1.00 / 1KG
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2020-01-03
- CAS:1202916-90-2
- Min. Order: 1KG
- Purity: 99%
- Supply Ability: 200kg
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| Product Name: | CX6258 | | Synonyms: | (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one CX-6258;CX6258 (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX6258;CX-6258/CX6258;(Z)-5-CHLORO-3-((5-(3-(4-METHYL-1,4-DIAZEPANE-1-CARBONYL)PHENYL)FURAN-2-YL)METHYLENE)INDOLIN-2-ONE.HCL;(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX-6258, >=98%;CX-6258;CX6258;CX 6258 | | CAS: | 1202916-90-2 | | MF: | C26H24ClN3O3 | | MW: | 461.94 | | EINECS: | | | Product Categories: | Inhibitors;JAK;STAT;JAK/STAT | | Mol File: | 1202916-90-2.mol |  |
| | CX6258 Chemical Properties |
| Boiling point | 697.8±55.0 °C(Predicted) | | density | 1.309±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | insoluble in EtOH; ≥11.15 mg/mL in DMSO; ≥2.575 mg/mL in H2O with gentle warming | | form | solid | | pka | 11.38±0.20(Predicted) | | color | Yellow to orange |
| | CX6258 Usage And Synthesis |
| Uses | CX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor. | | Biological Activity | pim kinases (provirus integration site for moloney murine leukemia virus) are a family of serine/threonine kinases that regulate cell survival. this family of kinases is composed of three different isoforms (pim-1, pim-2, and pim-3). the simultaneous inhibition of pim-1, pim-2, and pim-3 kinases is emerging as a promising strategy for anticancer drug development. cx-6258 is a potent, selective, and orally efficacious pan-pim kinases inhibitor. | | in vitro | cx-6258 exhibited in vitro synergy with chemotherapeutics. the antiproliferative activity of cx-6258 was examined against a panel of cell lines derived from human solid tumors and hematological malignancies. cx-6258 demonstrated robust antiproliferative potencies against all cell lines tested [1]. | | in vivo | cx-6258 was evaluated in two human tumor xenograft growth efficacy models, acute myeloid leukemia mv-4-11, and prostate adenocarcinoma pc3. the drug exhibited dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (tgi) and a 100 mg/kg dose producing 75% tgi. in addition, cx-6258 displayed significant efficacy in vivo in two xenograft models representing the diseases where pim kinases had been shown to play an important role [1]. | | target | Pim1 | | references | [1] haddach m, michaux j, schwaebe mk, et al. discovery of cx-6258. a potent, selective, and orally efficacious pan-pim kinases inhibitor. acs med chem lett. 2011;3(2):135-9. |
| | CX6258 Preparation Products And Raw materials |
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