CX6258

CX6258 Suppliers list
Company Name: ATK CHEMICAL COMPANY LIMITED
Tel: +undefined-21-51877795
Email: ivan@atkchemical.com
Products Intro: Product Name:CX6258
CAS:1202916-90-2
Purity:98% Package:10MG;50MG;100MG,1G,5G,10G.100G
Company Name: career henan chemical co
Tel: +86-0371-86658258 +8613203830695
Email: factory@coreychem.com
Products Intro: Product Name:CX6258
CAS:1202916-90-2
Purity:99% Package:1KG;1USD
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:CX-6258;CX 6258;CX6258
CAS:1202916-90-2
Package:1 mL * 10mM (in DMSO);10 mg;2 mg;25 mg;5 mg;50 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: HANGZHOU CLAP TECHNOLOGY CO.,LTD
Tel: 86-571-88216897,88216896 13588875226
Email: sales@hzclap.com
Products Intro: Product Name:CX-6258
CAS:1202916-90-2
Purity:8699% Package:10kg 25kg 200 kilograms per barrel Remarks:good
Company Name: Shenzhen Shengda Pharma Limited
Tel: 755-85269922 +8613424394241
Email: sales@shengdapharm.com
Products Intro: Product Name:CX-6258
CAS:1202916-90-2
Purity:98 Package:1ASSAYS;USD

CX6258 manufacturers

  • CX6258
  • CX6258 pictures
  • $1.00 / 1KG
  • 2020-01-03
  • CAS:1202916-90-2
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 200kg
CX6258 Basic information
Product Name:CX6258
Synonyms:(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one CX-6258;CX6258 (3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX6258;CX-6258/CX6258;(Z)-5-CHLORO-3-((5-(3-(4-METHYL-1,4-DIAZEPANE-1-CARBONYL)PHENYL)FURAN-2-YL)METHYLENE)INDOLIN-2-ONE.HCL;(3E)-5-Chloro-3-[[5-[3-[(hexahydro-4-methyl-1H-1,4-diazepin-1-yl)carbonyl]phenyl]-2-furanyl]methylene]-1,3-dihydro-2H-indol-2-one;CX-6258, >=98%;CX-6258;CX6258;CX 6258
CAS:1202916-90-2
MF:C26H24ClN3O3
MW:461.94
EINECS:
Product Categories:Inhibitors;JAK;STAT;JAK/STAT
Mol File:1202916-90-2.mol
CX6258 Structure
CX6258 Chemical Properties
Boiling point 697.8±55.0 °C(Predicted)
density 1.309±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility insoluble in EtOH; ≥11.15 mg/mL in DMSO; ≥2.575 mg/mL in H2O with gentle warming
form solid
pka11.38±0.20(Predicted)
color Yellow to orange
Safety Information
MSDS Information
CX6258 Usage And Synthesis
UsesCX-6258 is a potent, selective, and orally efficacious pan-Pim kinases inhibitor.
Biological Activitypim kinases (provirus integration site for moloney murine leukemia virus) are a family of serine/threonine kinases that regulate cell survival. this family of kinases is composed of three different isoforms (pim-1, pim-2, and pim-3). the simultaneous inhibition of pim-1, pim-2, and pim-3 kinases is emerging as a promising strategy for anticancer drug development. cx-6258 is a potent, selective, and orally efficacious pan-pim kinases inhibitor.
in vitrocx-6258 exhibited in vitro synergy with chemotherapeutics. the antiproliferative activity of cx-6258 was examined against a panel of cell lines derived from human solid tumors and hematological malignancies. cx-6258 demonstrated robust antiproliferative potencies against all cell lines tested [1].
in vivocx-6258 was evaluated in two human tumor xenograft growth efficacy models, acute myeloid leukemia mv-4-11, and prostate adenocarcinoma pc3. the drug exhibited dose dependent efficacy, with a 50 mg/kg dose producing 45% tumor growth inhibition (tgi) and a 100 mg/kg dose producing 75% tgi. in addition, cx-6258 displayed significant efficacy in vivo in two xenograft models representing the diseases where pim kinases had been shown to play an important role [1].
targetPim1
references[1] haddach m, michaux j, schwaebe mk, et al. discovery of cx-6258. a potent, selective, and orally efficacious pan-pim kinases inhibitor. acs med chem lett. 2011;3(2):135-9.
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