GKA-50; GKA 50
中文名称 | GKA-50; GKA 50 |
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中文同义词 | 化合物 T11401 |
英文名称 | GKA-50 |
英文同义词 | GKA 50;GKA50;GKA-50;6-[[3-[(1S)-2-Methoxy-1-Methylethoxy]-5-[(1S)-1-Methyl-2-phenylethoxy]benzoyl]aMino]-3-pyridinecarboxylic Acid;OCBMECSFDVUYQN-ROUUACIJSA-N;GKA-50; GKA 50;3-Pyridinecarboxylic acid, 6-[[3-[(1S)-2-methoxy-1-methylethoxy]-5-[(1S)-1-methyl-2-phenylethoxy]benzoyl]amino]- |
CAS号 | 851884-87-2 |
分子式 | C26H28N2O6 |
分子量 | 464.51 |
EINECS号 | |
相关类别 | |
Mol文件 | 851884-87-2.mol |
结构式 |
GKA-50; GKA 50 性质
沸点 | 607.0±55.0 °C(Predicted) |
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密度 | 1.247±0.06 g/cm3(Predicted) |
储存条件 | -20°C |
溶解度 | DMSO:可溶15mg/mL,澄清 |
形态 | 粉末 |
酸度系数(pKa) | 3.49±0.10(Predicted) |
颜色 | 白色至米色 |
GKA50 (0.01-100 μM; 24 hours) enhances INS-1 cell proliferation with EC
50
values ranging from 1 to 2 μM.
GKA50 (1.2 μM+40 μM glucose; 2-4 days) treatment reduces apoptosis induced by chronic high glucose in INS-1 cells.
GKA50 activates human glucokinase enzymatic activity with an EC
50
of 0.022 μM. GKA50 stimulates insulin secretion in the pancreatic insulinoma cell line, INS-1, with an EC
50
of 0.065 μM. GKA50 reduces chronic-high-glucose-induced apoptosis via modulation of glucokinase and apoptotic protein BAD.
Cell Proliferation Assay
Cell Line: | INS-1 cells (starved overnight with 3 μM glucose) |
Concentration: | 0.01-100 μM |
Incubation Time: | 24 hours |
Result: | Stimulated cell proliferation in a dose-dependent manner, with EC 50 values ranging from 1 to 2 μM. |
GKA50 (1-30 mg/kg; p.o.) gives significant glucose lowering in an oral glucose tolerance test.
Animal Model: | High-fat-fed obese female Zucker (fa/fa) rats |
Dosage: | 1, 3, 10, 30 mg/kg |
Administration: | Oral administration |
Result: | Significant percentage glucose lowering. |
更新日期 | 产品编号 | 产品名称 | CAS号 | 包装 | 价格 |
---|---|---|---|---|---|
2024/04/30 | HY-15671 | GKA-50; GKA 50 GKA50 | 851884-87-2 | 1mg | 650元 |
2024/04/30 | HY-15671 | GKA-50; GKA 50 GKA50 | 851884-87-2 | 5mg | 1600元 |