| Company Name: |
SPIRO PHARMA
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| Tel: |
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| Email: |
eric_feng1954@126.com |
| Products Intro: |
Product Name:ITMN 4077
CAS:790305-05-4
Purity:95% -98%HPLC Package:1GR;10GR;50GR;100GR;250GR;500GR;1KG;5KG;10KG;100KG
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ITMN 4077 manufacturers
- ITMN4077
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- $30.00 / 10mg
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2025-11-09
- CAS:790305-05-4
- Min. Order:
- Purity: 99.78%
- Supply Ability: 10g
- ITMN 4077
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- $0.00 / 100mg
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2021-09-16
- CAS:790305-05-4
- Min. Order: 100mg
- Purity: 99%
- Supply Ability: 100KG
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| | ITMN 4077 Basic information |
| Product Name: | ITMN 4077 | | Synonyms: | ITMN 4077;t - butyl (2R,6S,13aS,14aR,16aS,Z) - 14a - (cyclopropylsulfonylcarbamoyl) - 2 - hydroxy - 5,16 - dioxo - 1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a - hexadecahydrocyclopropa[e]pyrrolo[1,2 - a][1,4]diazacyclopentadecin - 6 - ylcarbamate;Carbamic acid, N-[(2R,6S,12Z,13aS,14aR,16aS)-14a-[[(cyclopropylsulfonyl)amino]carbonyl]-1,2,3,5,6,7,8,9,10,11,13a,14,14a,15,16,16a-hexadecahydro-2-hydroxy-5,16-dioxocyclopropa[e]pyrrolo[1,2-a][1,4]diazacyclopentadecin-6-yl]-, 1,1-dimethylethyl ester;ITMN-4077,ITMN4077;ITMN4077, 10 mM in DMSO | | CAS: | 790305-05-4 | | MF: | C26H40N4O8S | | MW: | 568.68 | | EINECS: | | | Product Categories: | | | Mol File: | 790305-05-4.mol |  |
| | ITMN 4077 Chemical Properties |
| density | 1.37±0.1 g/cm3(Predicted) | | storage temp. | Sealed in dry,Store in freezer, under -20°C | | pka | 4.44±0.60(Predicted) | | form | Solid | | color | White to off-white |
| | ITMN 4077 Usage And Synthesis |
| Uses | ITMN 4077 is a macrocyclic inhibitor against Hepatitis C Virus (HCV) NS3 protease (EC50: 2131 nM)[1][2]. | | References | [1] Rajagopalan R, et al. Inhibition and binding kinetics of the hepatitis C virus NS3 protease inhibitor ITMN-191 reveals tight binding and slow dissociative behavior. Biochemistry. 2009 Mar 24;48(11):2559-68. DOI:10.1021/bi900038p
[2] Jiang Y, et al. Discovery of danoprevir (ITMN-191/R7227), a highly selective and potent inhibitor of hepatitis C virus (HCV) NS3/4A protease. J Med Chem. 2014 Mar 13;57(5):1753-69. DOI:10.1021/jm400164c |
| | ITMN 4077 Preparation Products And Raw materials |
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