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| | ACT-132577 Basic information |
| Product Name: | ACT-132577 | | Synonyms: | N-Despropyl Macitentan;ACT-132577;N-[5-(4-Bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]sulfamide;Aprocitentan;5-(4-BROMOPHENYL)-4-[2-(5-BROMOPYRIMIDIN-2-YL)OXYETHOXY]-6-(SULFAMOYLAMINO)PYRIMIDINE;APROCITENTAN; ACT-132577; ACT 132577; ACT132577; DESPROPYL MACITENTAN;Despropyl Macitentan;Sulfamide, N-[5-(4-bromophenyl)-6-[2-[(5-bromo-2-pyrimidinyl)oxy]ethoxy]-4-pyrimidinyl]- | | CAS: | 1103522-45-7 | | MF: | C16H14Br2N6O4S | | MW: | 546.19 | | EINECS: | | | Product Categories: | APIS | | Mol File: | 1103522-45-7.mol |  |
| | ACT-132577 Chemical Properties |
| Melting point | 139-141°C | | Boiling point | 705.0±70.0 °C(Predicted) | | density | 1.841±0.06 g/cm3(Predicted) | | storage temp. | -20°C Freezer | | solubility | Chloroform (Slightly, Heated), Methanol (Slightly, Heated) | | form | Solid | | pka | 13.56±0.60(Predicted) | | color | White to Off-White |
| | ACT-132577 Usage And Synthesis |
| Uses | N-Despropyl-macitentan, is an active metabolite which is part of a family of endothelin receptor antagonist that allows for treatment of pulmonary arterial hypertension (PAH) | | Definition | ChEBI: ACT-132577 is a member of the class of sulfamides in which one of the amino groups of sulfonamide is substituted by a 5-(4-bromophenyl)-6-{2-[(5-bromopyrimidin-2-yl)oxy]ethoxy}pyrimidin-4-yl group. An active metabolite of macitentan (obtained by oxidative depropylation), an orphan drug used for the treatment of pulmonary arterial hypertension. It has a role as an antihypertensive agent, an endothelin receptor antagonist, a drug metabolite and a xenobiotic metabolite. It is an aromatic ether, an organobromine compound, a member of pyrimidines and a member of sulfamides. It is functionally related to an ethylene glycol. |
| | ACT-132577 Preparation Products And Raw materials |
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