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| | PLpro inhibitor Basic information |
| Product Name: | PLpro inhibitor | | Synonyms: | PLpro inhibitor;5-(Acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]benzamide;5-Acetylamino-2-methyl-N-(1R-naphthalen-1-yl-ethyl)benzamide;5-(acetylamino)-2-methyl-N-[(1R)-1-(1-naphthalenyl)ethyl]-;BENZAMIDE; 5-(ACETYLAMINO)-2-METHYL-N-[(1R)-1-(1-NAPHTHALENYL)ETHYL]-;5-acetamido-2-methyl-N-[2-(1-naphthalenyl)ethyl]benzamide;5-acetylamino-2-methyl-N-[(R)-1-(1-naphthyl)ethyl]benzamide;5-acetamido-2-methyl-n-(2-naphthalen-1-ylethyl)benzamide | | CAS: | 1093070-14-4 | | MF: | C22H22N2O2 | | MW: | 346.42 | | EINECS: | | | Product Categories: | | | Mol File: | 1093070-14-4.mol |  |
| | PLpro inhibitor Chemical Properties |
| Boiling point | 584.7±50.0 °C(Predicted) | | density | 1.189±0.06 g/cm3(Predicted) | | storage temp. | Sealed in dry,Room Temperature | | solubility | DMF: 30 mg/ml; DMSO: 30 mg/ml | | form | Powder | | pka | 14.13±0.46(Predicted) |
| | PLpro inhibitor Usage And Synthesis |
| Definition | ChEBI: KOM70144 is a benzamide that is GRL-0617 in which one of the hydrogen's of the primary amino group is replaced by an acetyl group. It an inhibitor of SARS-CoV and SARS-CoV-2 papain-like protease (PLpro) with an IC50 of 2.6 muM and 5.0 muM, respectively. It also inhibits SARS-CoV and SARS-CoV-2 infection of Vero E6 cells in vitro (EC50 values are 13.1 and 21 muM, respectively). It has a role as a protease inhibitor and an anticoronaviral agent. It is a member of naphthalenes, a member of benzamides, a secondary carboxamide and a member of acetamides. It is functionally related to a GRL-0617. | | storage | Store at -20°C |
| | PLpro inhibitor Preparation Products And Raw materials |
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