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| | c-GpAp Chemical Properties |
| Boiling point | 1159.9±75.0 °C(Predicted) | | density | 2.61±0.1 g/cm3(Predicted) | | storage temp. | -20°C | | pka | 0.96±0.70(Predicted) | | form | powder | | color | white to beige | | Water Solubility | Water : 20 mg/mL (29.66 mM) |
| | c-GpAp Usage And Synthesis |
| Uses | cGAMP sodium salt has been used in cGAS-cGAMP Activity Assay. | | Uses | c-GpAp induces the production of interferons, a usual response to triggers in the cytoplasm of mammalian cells by the presence of DNA. | | Definition | ChEBI: C-GMP-AMP is a cyclic purine dinucleotide that consists of AMP and GMP units cyclised via 3',5'-linkages. It is an adenyl ribonucleotide, a cyclic purine dinucleotide and a guanyl ribonucleotide. It is a conjugate acid of a c-GMP-AMP(2-). | | Biochem/physiol Actions | cGAMP induces the formation of cytokines (interferon-β, interferon-γ), activation of dendritic cells and CD8+ T cell cross priming. Through this action, it promotes innate immune response. cGAMP possesses antitumor activity and is prefered for immunotherapy in cancer treatment. | | in vivo | cGAMP promotes the antigen-specific cytokine production by spleen cells of immunized mice[2].
| Animal Model: | Female C57BL/6 (H-2b) mice 6–8 weeks old[2] | | Dosage: | 5 μg | | Administration: | Nostril mucosal adjuvant | | Result: | Higher titers of ovalbumin (OVA)-specific IgA and total IgG as well as IgG1 and IgG2c in the sera of mice immunized with cGAMP-adjuvanted OVA as compared to sera from OVA-immunized mice. |
| | storage | +4°C |
| | c-GpAp Preparation Products And Raw materials |
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