| Company Name: |
Haoyuan Chemexpress Co., Ltd.
|
| Tel: |
021-58950125 |
| Email: |
info@chemexpress.com |
| Products Intro: |
Product Name:VT-464 (R enantiomer)
CAS:1375603-38-5
Purity:>98% Package:2333RMB/2mg
|
| Company Name: |
MedChemexpress LLC
|
| Tel: |
021-58955995 |
| Email: |
sales@medchemexpress.cn |
| Products Intro: |
Product Name:VT-464 (R enantiomer)
CAS:1375603-38-5
Purity:>98% Package:2333RMB/2mg
|
| Company Name: |
LETOPHARM LIMITED
|
| Tel: |
+86-21-5821 5861 |
| Email: |
sales@letopharm.com |
| Products Intro: |
Product Name:VT-464 (R enantioMer)
CAS:1375603-38-5
|
VT-464 (R enantioMer) manufacturers
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| | VT-464 (R enantioMer) Basic information |
| Product Name: | VT-464 (R enantioMer) | | Synonyms: | VT-464 (R enantioMer);Seviteronel R entiomer;1H-1,2,3-Triazole-5-methanol, α-[6,7-bis(difluoromethoxy)-2-naphthalenyl]-α-(1-methylethyl)-, (+)- | | CAS: | 1375603-38-5 | | MF: | C18H17F4N3O3 | | MW: | 399.35 | | EINECS: | | | Product Categories: | | | Mol File: | 1375603-38-5.mol |  |
| | VT-464 (R enantioMer) Chemical Properties |
| Boiling point | 536.3±45.0 °C(Predicted) | | density | 1.393±0.06 g/cm3(Predicted) | | storage temp. | Store at -20°C | | solubility | DMSO : ≥ 100 mg/mL (250.41 mM) | | form | Solid | | pka | 8.69±0.70(Predicted) | | color | White to off-white |
| | VT-464 (R enantioMer) Usage And Synthesis |
| Uses | Seviteronel R enantiomer (VT-464 R enantiomer) is the R enantiomer of Seviteronel (VT-464), which is a potent CYP17 lyase inhibitor(h-Lyase IC50=69 nM); Seviteronel (VT-464) R enantiomer's activity is unknown. | | IC 50 | CYP17 | | References | [1] Rafferty SW, et al. Highly-selective 4-(1,2,3-triazole)-based P450c17a 17,20-lyase inhibitors.
Bioorg Med Chem Lett. 2014 Jun 1;24(11):2444-7. DOI:10.1016/j.bmcl.2014.04.024
[2] Sankar N. Maity, et al. Abstract 4772: Efficacy of VT-464, a novel selective inhibitor of cytochrome P450 17,20-lyase, in castrate-resistant prostate cancer models.
Cancer Research: April 15, 2013; Volume 73, Issue 8, Supplement 1 |
| | VT-464 (R enantioMer) Preparation Products And Raw materials |
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