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Sigma-Aldrich
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Product Name:SR-3576
CAS:1164153-22-3
Purity:>=98% (HPLC) Package:25MG Remarks:S8201-25MG
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| Company Name: |
BOC Sciences
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| Products Intro: |
Product Name:SR 3576
CAS:1164153-22-3
Purity:≥97% Remarks:SR 3576 is a potent and selective JNK3 inhibitor (IC50 = 7 nM) with > 2800-fold selectivity over p38.
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| | 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Basic information |
| Product Name: | 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide | | Synonyms: | 3-(5-(3-m-Tolylureido)-1H-indazol-1-yl)-N-(3,4,5-trimethoxyphenyl)benzamide;SR-3576;JNK3 Inhibitor XII, SR-3576;3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide;JNK3 Inhibitor XII, SR-3576 - CAS 1164153-22-3 - Calbiochem;3-[4-(3-m-Tolyl-ureido)-pyrazol-1-yl]-N-(3,4,5-trimethoxy-phenyl)-benzamide;JNK3 Inhibitor XII;SR-3576 >=98% (HPLC) | | CAS: | 1164153-22-3 | | MF: | C27H27N5O5 | | MW: | 501.53 | | EINECS: | | | Product Categories: | | | Mol File: | 1164153-22-3.mol | ![3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Structure](CAS/20180629/GIF/1164153-22-3.gif) |
| | 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Chemical Properties |
| Boiling point | 557.7±50.0 °C(Predicted) | | density | 1.27±0.1 g/cm3(Predicted) | | storage temp. | 2-8°C | | solubility | DMSO: ≥20mg/mL | | form | powder | | pka | 11.51±0.70(Predicted) | | color | light brown to brown | | Stability: | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 1 month. |
| WGK Germany | 3 | | HS Code | 2933399990 |
| | 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Usage And Synthesis |
| Description | SR-3576 (1164153-22-3) is a potent and selective JNK3 inhibitor. IC50?= 7nM and >2800-fold selective over p38.1?Cell permeable. | | Uses | SR 3576 is a JNK-3 selective inhibitor. | | General Description | A cell-permeable pyrazolourea compound that acts as a potent, ATP binding pocket-targeting, and JNK3-selective inhibitor (IC50 = 7 nM), inhibiting JNK1 only at much higher concentrations (IC50 = 170 nM) and exhibiting little activity against p38 even at concentrations as high as 20 μM. Shown to inhibit streptozotocin- (Cat. No. 572201) induced c-jun phosphorylation in INS-1 rat β-pancreatic cells (IC50 = 1.3 μM). | | Biochem/physiol Actions | SR-3576 is a small molecule inhibitor belonging to aminopyrazole class that selectively inhibits JNK3 with >2800 fold selectively over p38.1 | | storage | Store at -20°C | | References | 1) Kamenecka?et al. (2009),?Structure-activity relationships and X-ray structures describing the selectivity of aminopyrazole inhibitors for c-Jun N-terminal kinase 3 (JNK3) over p38; J. Biol. Chem.,?284?12853 |
| | 3-[4-[[[(3-Methylphenyl)amino]carbonyl]amino]-1H-pyrazol-1-yl]-N-(3,4,5-trimethoxyphenyl)-benzamide Preparation Products And Raw materials |
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