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7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole

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7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Suppliers list
Company Name: TargetMol Chemicals Inc.
Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Products Intro: Product Name:Gue1654；Gue 1654;Gue-1654
CAS:397290-30-1
Package:100 mg；500 mg Remarks:REAGENT;FOR LABORATORY USE ONLY
Company Name: Aladdin Scientific
Tel: +1-833-552-7181
Email: sales@aladdinsci.com
Products Intro: Product Name:Gue 1654
CAS:397290-30-1
Purity:>=97%(HPLC) Package:$139.9/10mg;$569.9/50mg;Bulk package Remarks:97%(HPLC)
Company Name: Guangzhou Isun Pharmaceutical Co., Ltd  
Tel: 020-39119399 18927568969
Email: isunpharm@qq.com
Products Intro: Product Name:Gue1654
CAS:397290-30-1
Purity:98% (HPLC) Package:5MG; 25MG; 100MG; 1G
Company Name: EMMX Biotechnology LLC  
Tel: 888-539-0666
Email: info@emmx.com
Products Intro: Product Name:Gue 1654
CAS:397290-30-1
Purity:98% HPLC Package:5mg;10mg;25mg;50mg;100mg;250mg;500mg;1g
Company Name: BOC Sciences  
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Email: info@bocsci.com
Products Intro: Product Name:Gue 1654
CAS:397290-30-1
Purity:≥97% by HPLC Remarks:Gue 1654 is an oxoeicosanoid receptor 1 (OXE-R) modulator selectively inhibiting Gβγ but not Gαi signaling upon activation of the Gαi-βγ heterotrimer by OXE-R. Gue 1654 was shown to inhibit Gβγ-mediat
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Basic information
Product Name:7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole
Synonyms:7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole;Gue1654;Gue-1654 (Gue 1654;N-[7-(Methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenylbenzeneacetamide;Gue1654 >=98% (HPLC);Benzeneacetamide, N-[7-(methylthio)benzo[1,2-d:4,3-d']bisthiazol-2-yl]-α-phenyl- (9CI)
CAS:397290-30-1
MF:C23H17N3OS3
MW:447.59558
EINECS:
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Mol File:397290-30-1.mol
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Structure
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Chemical Properties
density 1.44±0.1 g/cm3(Predicted)
storage temp. 2-8°C
solubility DMSO: soluble5mg/mL (clear solution; warmed)
form powder
pka10.58±0.43(Predicted)
color white to beige
Safety Information
Hazard Codes Xn
Risk Statements 22
WGK Germany 3
MSDS Information
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Usage And Synthesis
DescriptionGue1654 is a Gβγ-signaling-biased 5-OxoETE receptor antagonist. It inhibits neutrophil and eosinophil shape change and chemotaxis induced by 5-OxoETE (Item No. 34250) but not chemoattractant C5a or prostaglandin D2 (PGD2; ). Gue1654 inhibits 5-OxoETE-induced Gβγ-mediated inositol monophosphate (IP1) production in HEK293 cells transiently expressing the 5-OxoETE receptor, an effect that can be blocked by the Gβγ-inhibitor gallein, but has no effect on IP1 production induced by stimulation of endogenous Gαq-linked muscarinic receptors. In a bioluminescence resonance energy transfer (BRET) assay, Gue1654 reduces the 5-OxoETE-induced, but not basal, BRET fluorescence response, indicating disruption of the interaction between ligand-activated 5-OxoETE receptor and Gβγ.
UsesGue 1654 is a selective inhibitor of OXE-R Gβγ signaling.
7-(Methylthio)-2-[(2,2-diphenylacetyl)amino]benzo[1,2-d:4,3-d′]bisthiazole Preparation Products And Raw materials
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