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Diphenylamine hydrochloride manufacturers
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| | Diphenylamine hydrochloride Basic information |
| Product Name: | Diphenylamine hydrochloride | | Synonyms: | N-PHENYLANILINE HYDROCHLORIDE;Diphenylamine hydrochloride,99%;DiphenylaMine Hydrochlori...;n-phenyl-benzenaminhydrochloride;diphenylammonium chloride;DiphenylamineHCl;2-propenoic acid 1,2,3,4,4a,5,6,7,8,8a-decahydronaphthalen-2-yl ester;Diphenylamine Hydrochloride > | | CAS: | 537-67-7 | | MF: | C12H12ClN | | MW: | 205.68 | | EINECS: | 208-675-5 | | Product Categories: | | | Mol File: | 537-67-7.mol |  |
| | Diphenylamine hydrochloride Chemical Properties |
| Hazard Codes | Xi | | Risk Statements | 36/37/38 | | Safety Statements | 37/39-26 | | TSCA | TSCA listed | | HS Code | 2921.44.7000 |
| Provider | Language |
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ACROS
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| | Diphenylamine hydrochloride Usage And Synthesis |
| Chemical Properties | white crystalline powder | | Uses | Diphenylamine hydrochloride (N-Phenylaniline hydrochloride) is an antihyperglycemic agent with oral activity and a common structure in non-steroidal anti-inflammatory drugs (NSAIDs) that uncouples oxidative phosphorylation in mitochondria, leading to a decrease in hepatic cell ATP levels and causing liver cell damage. Diphenylamine hydrochloride is also an industrial antioxidant, a dyeing mordant, and is used in agriculture as an antifungal and antibacterial agent[1][2][3][4]. | | in vivo | Diphenylamine hydrochloride is excreted in rats through urine and bile[1].
Diphenylamine (10 mg/kg, orally, single dose) hydrochloride lowers blood sugar in hyperglycemic rabbits[2]. | Animal Model: | Hyperglycemic rabbit[2] | | Dosage: | 10 mg/kg; single dose | | Administration: | Oral | | Result: | Reduced blood sugar by 61.4% two hours after administration. |
| | References | [1] W E Alexander, et al. Metabolism of diphenylamine in the rat, rabbit and man. Food Cosmet Toxicol. 1965 Oct;3(4):571-9. DOI:10.1016/s0015-6264(65)80203-6
[2] M S Karawya, wt al. Diphenylamine, an antihyperglycemic agent from onion and tea. J Nat Prod. 1984 Sep-Oct;47(5):775-80. DOI:10.1021/np50035a003
[3] Safe S, et al. Identification of toxic impurities in commercial diphenylamine. Bull Environ Contam Toxicol. 1977 Feb;17(2):204-7. DOI:10.1007/BF01685551
[4] Masubuchi Y, et al. Possible mechanism of hepatocyte injury induced by diphenylamine and its structurally related nonsteroidal anti-inflammatory drugs. J Pharmacol Exp Ther. 2000 Mar;292(3):982-7. PMID:10688613 |
| | Diphenylamine hydrochloride Preparation Products And Raw materials |
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