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Phthalimide

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Products Intro: Product Name:Phthalimide
CAS:85-41-6
Purity:0.99 Package:25kg;5KG;1KG
Company Name: Capot Chemical Co.,Ltd.
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Products Intro: Product Name:O-Phthalimide
CAS:85-41-6
Purity:98% (Min,GC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
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CAS:85-41-6
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CAS:85-41-6
Purity:0.99 Package:25KG,5KG;1KG;500G
Company Name: Hangzhou FandaChem Co.,Ltd.
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CAS:85-41-6
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Phthalimide manufacturers

  • O-Phthalimide
  • $17.50 / KG
  • 2022-01-14
  • CAS:85-41-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 10kg
  • O-Phthalimide
  • $17.50 / KG
  • 2022-01-14
  • CAS:85-41-6
  • Min. Order: 1KG
  • Purity: 99%
  • Supply Ability: 100KG
  • Phthalimide
  • $17.50 / KG
  • 2022-01-14
  • CAS:85-41-6
  • Min. Order: 1KG
  • Purity: 0.99
  • Supply Ability: 1KG
Phthalimide Basic information
Product Name:Phthalimide
Synonyms:Potassium phthalylimide;LABOTEST-BB LTBB000782;ISOINDOLE-1,3-DIONE;1,3-dihydro-1,3-dioxoisoindole;PHTHALIMIDE,REAGENT;PHTHALIMIDE / 2,5-ISOINDOLEDIONE;2H-Isoindole-1,3-dione;Isoindoline-1,3-dione
CAS:85-41-6
MF:C8H5NO2
MW:147.13
EINECS:201-603-3
Product Categories:Thiazines ,Thiophenes ,Thiazoles;intermediates;pharmacetical;API intermediates
Mol File:85-41-6.mol
Phthalimide Structure
Phthalimide Chemical Properties
Melting point 232-235 °C(lit.)
Boiling point 366 °C
density 1.21
refractive index 1.4700 (estimate)
Fp 165 °C
storage temp. Store below +30°C.
solubility water: slightly soluble(lit.)
pka8.3(at 25℃)
form Crystalline Flakes
color White to slightly yellow
PH3.8 (0.6g/l, H2O)
Water Solubility <0.1 g/100 mL at 19.5 ºC
Sublimation 366 ºC
Merck 14,7373
BRN 118522
InChIKeyXKJCHHZQLQNZHY-UHFFFAOYSA-N
CAS DataBase Reference85-41-6(CAS DataBase Reference)
NIST Chemistry ReferencePhthalimide(85-41-6)
EPA Substance Registry SystemPhthalimide (85-41-6)
Safety Information
Risk Statements 20/21/22-36/37/38-40
Safety Statements 22-24/25
WGK Germany 1
RTECS TI3920000
Autoignition Temperature>500 °C
TSCA Yes
HS Code 29251995
Hazardous Substances Data85-41-6(Hazardous Substances Data)
ToxicityLD50 orally in Rabbit: > 10000 mg/kg LD50 dermal Rabbit > 7940 mg/kg
MSDS Information
ProviderLanguage
Phthalimide English
SigmaAldrich English
ACROS English
ALFA English
Phthalimide Usage And Synthesis
Chemical Propertieswhite to slightly yellowish crystalline flakes
UsesPhthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities.
UsesPhthalimide, C6H4(CO)2NH, is an imide of commercial and industrial importance, forming a number of interesting derivatives. With alcoholic potash, phthalimide forms a potassium derivative, C6H4 (CO)2 NK, which, when reacted with ethyl iodide (or other alkyl halides), yields ethylphthalimide, C6H4(CO)2 N C2H5. The latter product, when hydrolyzed with an acid or alkali, further yields ethylamine [CAS: 75-04-7] C2H7N. Such reaction chains are useful in the preparation of certain primary amines and their derivatives.
UsesPhthalimide is a reagent used to transform allyl- and alkyl halides into protected primary amines. Phthalimide analogues have been extensively used in medicinal chemistry owing to their wide spectrum of applications as anti-convulsant, anti-inflammatory, analgesic, hypolipidimic and immunomodulatory activities. Dyes and metabolites, Environmental Testing.
DefinitionChEBI: A dicarboximide that is 2,3-dihydro-1H-isoindole substituted by oxo groups at positions 1 and 3.
Synthesis Reference(s)Journal of the American Chemical Society, 111, p. 3725, 1989 DOI: 10.1021/ja00192a034
The Journal of Organic Chemistry, 45, p. 363, 1980 DOI: 10.1021/jo01290a038
Tetrahedron Letters, 34, p. 6907, 1993 DOI: 10.1016/S0040-4039(00)91827-6
General DescriptionWhite to light tan powder. Slightly acidic.
Air & Water ReactionsInsoluble in water.
Reactivity ProfileO-Phthalimide is an imide. Amides/imides react with azo and diazo compounds to generate toxic gases. Flammable gases are formed by the reaction of organic amides/imides with strong reducing agents. Amides are very weak bases (weaker than water). Imides are less basic yet and in fact react with strong bases to form salts. That is, they can react as acids. Mixing amides with dehydrating agents such as P2O5 or SOCl2 generates the corresponding nitrile. The combustion of these compounds generates mixed oxides of nitrogen (NOx). O-Phthalimide forms salts with bases.
Health HazardACUTE/CHRONIC HAZARDS: When heated to decomposition O-Phthalimide emits toxic fumes of nitrogen oxides.
Fire HazardLiterature sources indicate that O-Phthalimide is combustible.
Safety ProfileModerately toxic by intraperitoneal route. Mildly toxic by ingestion. An experimental teratogen. Other experimental reproductive effects. When heated to decomposition it emits toxic fumes of NOx.
Purification MethodsCrystallise the imide from EtOH (20mL/g) (charcoal), or sublime it. For potassium phthalimide see entry in “Metal-organic Compounds”, Chapter 5. [Beilstein 21/10 V 270.]
Tag:Phthalimide(85-41-6) Related Product Information
PHTHALAMIDE 2,5-Diaminobenzenesulfonic acid 9-Oxo Epinastine HBr 6-Chloromethylmorphanthridine 6-(Phthalimidomethyl)-6,11-dihydro-5H-dibenz[b,e]azepine 7-Bromo Epinastine Epinastine Impurity 3 DiHCl SKQNTLALARIPLX-UHFFFAOYSA-N 6-Aminomethyl-6,11-dihydro-5H-dibenz[b,e]azepine (E)-2-butenedioate N-[2-(Phenylmethyl)phenyl]-2-chloroacetamide 6-(Phthalimidomethyl)morphanthridine Epinastine Impurity 1 HCl 6-Aminomethyl-5,6-dihydromorphanthridine Epinastine EP Impurity A NA Diethyl phthalate Tiron o-Phenylenediamine