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J & K SCIENTIFIC LTD.
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010-82848833 400-666-7788 |
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| Products Intro: |
Product Name:Equisetin
CAS:57749-43-6
Package:1mg
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- EQUISETIN
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- $1.00 / 1g
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2019-12-26
- CAS:57749-43-6
- Min. Order: 1g
- Purity: ≥98%
- Supply Ability: g/kg/Ton
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| | EQUISETIN Basic information |
| Product Name: | EQUISETIN | | Synonyms: | EQUISETIN;LS-64262;2,4-Pyrrolidinedione, 5-(hydroxymethyl)-3-[hydroxy[(1S,2R,4aS,6R,8aR)-1,2,4a,5,6,7,8,8a-octahydro-1,6-dimethyl-2-(1E)-1-propen-1-yl-1-naphthalenyl]methylene]-1-methyl-, (3E,5S)-;(3E,5S)-3-[[(1S,2R,4aS,6R,8aR)-1,6-dimethyl-2-[(E)-prop-1-enyl]-4a,5,6,7,8,8a-hexahydro-2H-naphthalen-1-yl]-hydroxymethylidene]-5-(hydroxymethyl)-1-methylpyrrolidine-2,4-dione;Citalopram Impurity 39 | | CAS: | 57749-43-6 | | MF: | C22H31NO4 | | MW: | 373.49 | | EINECS: | | | Product Categories: | | | Mol File: | 57749-43-6.mol |  |
| | EQUISETIN Chemical Properties |
| Melting point | 117-118 °C | | Boiling point | 556.0±50.0 °C(Predicted) | | density | 1.180±0.06 g/cm3(Predicted) | | storage temp. | Hygroscopic, -20°C Freezer, Under inert atmosphere | | solubility | Acetone (Slightly), DMSO (Slightly), Methanol (Slightly) | | form | Solid | | pka | 4.50±1.00(Predicted) | | color | Pale Beige to Light Brown | | Stability: | Hygroscopic |
| HS Code | 29339900 | | Toxicity | mouse,LD50,intraperitoneal,63mg/kg (63mg/kg),Antimicrobial Agents and Chemotherapy. Vol. 5, Pg. 634, 1974. |
| | EQUISETIN Usage And Synthesis |
| Description | Equisetin is a fungal metabolite that has been isolated from Fusarium. It inhibits HIV-1 integrase 3’ end-processing and strand transfer activities. Equisetin inhibits the ATPase activity of rat liver mitochondria and mitoplasts stimulated by 2,4-dinitrophenol (Dnp) in a concentration-dependent manner (IC50 = ~8 nM per mg of protein for both). It also inhibits ADP-stimulated respiration and the mitochondrial transport of ATP, inorganic phosphate, and succinate. Epiequisetin is phytotoxic and inhibits the germination of various seeds and growth of young seedlings. | | Uses | The tetramic acid, equisetin, is produced by a number of species of Fusarium. Interest in equisetin emerged with reports of its inhibitory activity against HIV-1 integrase in vitro that was mechanistically distinct from previously described inhibitors. Equisetin inhibits 3' end-processing and strand transfer, as well as disintegration catalysed by either the full-length enzyme or the truncated integrase core. | | Uses | Equisetin is tetramic acid with antibiotic and cytotoxic activity, and a potent inhibitor of HIV-1 integrase. |
| | EQUISETIN Preparation Products And Raw materials |
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