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| | 2,3-Difluorobenzyl bromide Basic information |
| Product Name: | 2,3-Difluorobenzyl bromide | | Synonyms: | 2,3-Difluorobenzyl bromide 98%;2,3-Difluorobenzylbromide98%;2,3-Difluorophenyl bromide;α-Bromo-2,3-difluorotoluene ,98%;alpha-Bromo-2,3-difluorotoluene,98%;TIMTEC-BB SBB006681;ALPHA-BROMO-2,3-DIFLUOROTOLUENE;1-(BROMOMETHYL)-2,3-DIFLUORO-BENZENE | | CAS: | 113211-94-2 | | MF: | C7H5BrF2 | | MW: | 207.02 | | EINECS: | | | Product Categories: | Miscellaneous;Benzenes;Fluoro-contained benzyl bromide series;Aromatic compound | | Mol File: | 113211-94-2.mol |  |
| | 2,3-Difluorobenzyl bromide Chemical Properties |
| Boiling point | 190.5±25.0 °C(Predicted) | | density | 1.628 g/mL at 25 °C(lit.) | | refractive index | n20/D 1.528(lit.) | | Fp | 194 °F | | storage temp. | under inert gas (nitrogen or Argon) at 2-8°C | | form | clear liquid | | color | Colorless to Light yellow | | Specific Gravity | 1.628 | | Sensitive | Lachrymatory | | BRN | 7089244 | | CAS DataBase Reference | 113211-94-2(CAS DataBase Reference) | | NIST Chemistry Reference | 2,3-Difluorobenzyl bromide(113211-94-2) |
| | 2,3-Difluorobenzyl bromide Usage And Synthesis |
| Chemical Properties | clear colorless to light yellow liquid | | Uses | 2,3-Difluorobenzyl bromide was used in the synthesis of chemokine antagonists. | | Synthesis | Step 2 (MW-S2): phosphorus tribromide (6.7 mL, 69.44 mmol) was added dropwise to a solution of diethyl ether (250 mL) of 2,3-difluorobenzyl alcohol (20 g, 138.88 mmol) at -10 °C. The reaction mixture was stirred at -10 °C for 1 hour. Upon completion of the reaction, the reaction was quenched with saturated sodium bicarbonate solution. The organic layer was separated and the aqueous layer was extracted with diethyl ether (2 x 100 mL). The combined organic layers were washed sequentially with water (100 mL), brine (100 mL), dried with anhydrous sodium sulfate, filtered and concentrated in vacuum to give 20 g of 2,3-difluorobenzyl bromide (MW-52) as a light brown liquid, which can be used in the next reaction without further purification. | | References | [1] Journal of Medicinal Chemistry, 1988, vol. 31, # 5, p. 1005 - 1009
[2] Patent: WO2014/140279, 2014, A1. Location in patent: Page/Page column 88; 170 |
| | 2,3-Difluorobenzyl bromide Preparation Products And Raw materials |
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