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Erythromycin Estolate

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Products Intro: Product Name:Erythromycin 2'-propionate dodecyl sulfate
CAS:3521-62-8
Purity:99% Package:413/KG
Company Name: Henan DaKen Chemical CO.,LTD.
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Products Intro: Product Name:Erythromycin 2'-propionate dodecyl sulfate
CAS:3521-62-8
Purity:99% Package:100g,500g,1KG,10KG,100KG
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Products Intro: CAS:3521-62-8
Purity:99% Package:500G;1KG;5KG;25KG
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Products Intro: Product Name:Erythromycin estolate
CAS:3521-62-8
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Products Intro: CAS:3521-62-8
Erythromycin Estolate Basic information
Product Name:Erythromycin Estolate
Synonyms:eritroger;eromycin;erythromycin,propionate(ester),compd.withmonododecylsulfate(1:1);erythromycin5-(3-propionate)dodecylsulfate;erythromycinpropionate,compd.withdodecylsulfate;erythromycinpropionatelaurylsulfate;ERYTHROMYCIN ESTOLATE;ERYTHROMYCIN 2'-PROPANOATE DODECYL SULFATE SALT
CAS:3521-62-8
MF:C52H97NO18S
MW:1056.39
EINECS:222-532-4
Product Categories:-;Intermediates & Fine Chemicals;Pharmaceuticals
Mol File:3521-62-8.mol
Erythromycin Estolate Structure
Erythromycin Estolate Chemical Properties
Melting point 135-140°C dec.
Boiling point 743℃
density 1.0053 (rough estimate)
refractive index 1.6550 (estimate)
Fp >110°(230°F)
storage temp. -20°C Freezer
solubility chloroform: soluble4.0ML, clear, colorless (200 mg + 4.0 mL Chloroform)
pka6.9(at 25℃)
form neat
color white
Water Solubility Freely soluble in organic solvents, practically insoluble in water /n
Sensitive Light Sensitive
CAS DataBase Reference3521-62-8
Safety Information
Hazard Codes Xn,Xi
Risk Statements 22-42/43-36/37/38
Safety Statements 22-36-26
WGK Germany 3
RTECS KF5775000
HS Code 29419000
ToxicityLD50 orally in rats: >5000 mg/kg (Goldenthal)
MSDS Information
ProviderLanguage
Erythromycin 2'-propionate dodecyl sulfate English
SigmaAldrich English
Erythromycin Estolate Usage And Synthesis
Chemical PropertiesLong Needles
UsesMacrolides Antibiotics
UsesUsed as an antibacterial agent. LD50 >5000 mg/kg for oral administration to rats
Brand nameAntibio-aberel;Apo-erythro-s;Bio-exazol;Biometran;Biomicron;Chemthromycin;Cimetrin;Cusimicina balsamica;Doboiosol;Dowmicyn;Dreimicina;Duozplin vitaminado;Dynabiotal;Ees-200;Ees-400;E-mycine;Endoeritrina;Erimec;Erirobios;Eritrazol;Eritrobios;Eritrobiotic;Eritrocin;Eritrodes;Eritronicol;Eritropan;Eritroveinte;Eritrovienite;Eritrowolf;Eritro-wolf;Erymycin;Eryped;Ery-tar;Erythromictine;Erythro-prat;Ery-toxinal;Erytrodol;Erytro-prot;Eryt-toxinal;Espimina;Estimina;Estomiicina;Estomycin;Fesmicina;Ilosone pulvules;Ilosone ready-mix;Ilothycin;Kesso-mycin;Laucetin;Laurilin;Lauritran;Liferitrin;Loderm;Lubomycina;Lubomycine;Makrocyklina;Manilina;Marocid;Neo-ilolycina;Neo-iloticina;Niux;Novorythro;Propriocin enfante;Prospiocine;Proterytrin;Pulmomas;Purmycin;Ritromin;Roxo chemil;Roxochemil;Rp-mycin;Rubibacter;Selvicin;Spetrasone;Stella micina;Taimoxin;Togerin;Togrien;Tosinova;Tropoxin;Wyamycin s.
World Health Organization (WHO)Erythromycin estolate, a macrolide antibiotic, was introduced in 1958 for the treatment of gram-positive infections. By the early 1970s its use had been associated with a higher incidence of hepatic toxicity than that seen with other salts and esters of erythromycin. This led to its withdrawal by some regulatory authorities whereas others required the addition of a warning in the product information. Evidence that the estolate ester is more hepatotoxic than other salts or esters has subsequently been disputed. It has been claimed to be the most effective ester for treatment of Legionnaire's disease and preparations remain widely available. (Reference: (BMJOAE) British Medical Journal, 286, 1954, 1983)
General DescriptionErythromycin estolate, erythromycin propionate lauryl sulfate(Ilosone), is the lauryl sulfate salt of the 2'-propionateester of erythromycin. Erythromycin estolate is acid stableand absorbed as the propionate ester. The ester undergoesslow hydrolysis in vivo. Only the free base binds to bacterialribosomes. Some evidence, however, suggests that theester is taken up by bacterial cells more rapidly than thefree base and undergoes hydrolysis by bacterial esteraseswithin the cells. The incidence of cholestatic hepatitis is reportedlyhigher with the estolate than with other erythromycinpreparations.
Erythromycin estolate occurs as long needles that aresparingly soluble in water but soluble in organic solvents. administration for the treatment of serious infections,such as Legionnaires disease, or when oral administrationis not possible. Solutions are stable for 1 week whenrefrigerated.
Tag:Erythromycin Estolate(3521-62-8) Related Product Information
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