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Raloxifene

Raloxifene Suppliers list
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Raloxifene
CAS:84449-90-1
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:84449-90-1
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Mainchem Co., Ltd.
Tel: +86-0592-6210733
Email: sales@mainchem.com
Products Intro: Product Name:Raloxifene
CAS:84449-90-1
Company Name: Hubei Jusheng Technology Co.,Ltd.
Tel: 86-188-71490254
Email: peter@hubeijusheng.com
Products Intro: Product Name:raloxifene
CAS:84449-90-1
Purity:99% Package:5KG;1KG Remarks:C28H27NO4S
Company Name: 3B Pharmachem (Wuhan) International Co.,Ltd.  
Tel: 86-21-50328103 * 801、802、803、804 Mobile:18930552037
Email: 3bsc@sina.com
Products Intro: Product Name:Raloxifene hydrochloride;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-Methanonehydrochloride
CAS:84449-90-1
Purity:99% HPLC Package:1Mg ; 5Mg;10Mg ;100Mg;250Mg ;500Mg ;1g;2.5g ;5g ;10g
Raloxifene Basic information
Application in Particular Diseases
Product Name:Raloxifene
Synonyms:(6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)Methanone;[6-Hydroxy-2-(4-hydroxyphenyl)benzothien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]-methanone;(6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thiophen-3-yl)(4-(2-(piperidin-1-yl)ethoxy)phenyl)methan;RALOXIFEN;RALOXIFENE;[4-[2-(1-Piperidinyl) Ethoxy] Phenyl]methanone.HCL;RALOXAFINE;[6-Hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone
CAS:84449-90-1
MF:C28H27NO4S
MW:473.58
EINECS:686-786-1
Product Categories:Raloxifene;Intermediates & Fine Chemicals;Pharmaceuticals;Pharmaceutical intermediate
Mol File:84449-90-1.mol
Raloxifene Structure
Raloxifene Chemical Properties
Melting point 250-253°C
storage temp. Desiccate at +4°C
solubility DMSO: 28 mg/mL, soluble
form solid
color light yellow
CAS DataBase Reference84449-90-1(CAS DataBase Reference)
Safety Information
WGK Germany 3
HS Code 29349990
Hazardous Substances Data84449-90-1(Hazardous Substances Data)
MSDS Information
ProviderLanguage
Raloxifene English
Raloxifene Usage And Synthesis
Application in Particular DiseasesIn Osteoporosis:
  • Raloxifene is an estrogen agonist on bone but an antagonist on the breast and uterus. It is approved for prevention and treatment of postmenopausal osteoporosis. Other estrogen agonists/antagonists may be approved soon (e.g., bazedoxifene, lasofoxifene).
  • Raloxifene decreases vertebral fractures and increases spine and hip BMD, but to a lesser extent than bisphosphonates. After discontinuation, the beneficial effect is lost and bone loss returns to age- or disease-related rates.
  • Raloxifene (like tamoxifen) is associated with decreased breast cancer risk. Raloxifene is associated with decreases in total and low-density lipoprotein cholesterol, neutral effects on high-density lipoprotein cholesterol, but slight increases in triglycerides; no beneficial cardiovascular effects have yet been demonstrated.
  • Raloxifene is well tolerated overall. Hot flushes occur more frequently in women recently finishing menopause or discontinuing estrogen therapy (ET). Endometrial bleeding occurs rarely. Raloxifene is contraindicated in women with an active or past history of venous thromboembolism. Therapy should be stopped if a patient anticipates extended immobility.
Chemical PropertiesLight-Yellow Solid
UsesA nonsteroidal estrogen receptor mixed agonist/antagonist
DefinitionChEBI: A member of the class of 1-benzothiophenes that is 1-benzothiophene in which the hydrogens at positions 2, 3, and 6 have been replaced by p-hydroxyphenyl, p-[2-(piperidin-1-yl)ethoxy]benzoyl, and hydroxy groups, respectively.
Brand nameEvista (Lilly).
General DescriptionRaloxifene, [6-hydroxy-2-(4-hydroxyphenyl)benzo[b]thien-3-yl][4-[2-(1-piperidinyl)ethoxy]phenyl]methanone (Evista), is a benzothiophene derivativethat differs slightly from the triphenylethyleneSERMs. A key structural difference is the carbonyl “hinge”that connects the modified phenolic side chain to the benzothiophenering system. This hinge is the key structural elementthat leads to the differing actions at the ERs.Raloxifene, unlike tamoxifen and toremifene, has antagonistproperties on the endometrium and breast tissue and agonistproperties on bone and the cardiovascular system. The lackof agonist action on endometrial tissue has been suggestedas a reason for the lack of endometrial cancer associatedwith raloxifene use. Raloxifene is approved for the preventionand treatment of osteoporosis in postmenopausalwomen. It has also been investigated for preventing breastcancer in comparison with tamoxifen. Recent studies indicatesthat it has similar effectiveness to tamoxifen, but has apreferable side effect profile.
Biological ActivitySelective estrogen receptor modulator (SERM) that binds to ER α and ER β , and tissue-dependently activates or blocks estrogen-induced transcription. Acts as an antiestrogen in breast and uterine tissue, but displays estrogen agonist activity in bone. In D12 rat hypothalamic cells, inhibits progesterone receptor induction by estrogen with an IC 50 of 1 nM.
Raloxifene Preparation Products And Raw materials
Raw materialsMethanesulfonyl chloride-->Biphenyl-->Thianaphthene-->2-Bromo-4'-methoxyacetophenone-->Phenetole
Tag:Raloxifene(84449-90-1) Related Product Information
RALOXIFENE-D4-6'-GLUCURONIDE,RALOXIFENE 6-GLUCURONIDE RALOXIFENE-D4 BISMETHYL ETHER METHYL-1-(6-TERT-BUTYLDIMETHYLSYLYL-4'-HYDROXYRALOXIFENE-D4)-2,3,4-TRI-O-ACETYL-B-D-GLYCOPYRANURONATE METHYL-1-(4'-TERT-BUTYLDIMETHYLSYLYL-6-HYDROXYRALOXIFENE-D4)-2,3,4-TRI-O-ACETYL-B-D-GLYCOPYRANURONATE RALOXIFENE-D4 RALOXIFENE-D10 RALOXIFENE-D4, HYDROCHLORIDE 6-HYDROXY-4'-TERT-BUTYLDIMETHYLSYLYL-RALOXIFENE-D4 Raloxifene acetic acid, triethoxy-, ethyl ester 2-Ethoxyphenol Ethoxyquin RALOXIFENE HCL,RALOXIFENE HYDROCHLORIDE 2-Benzothienylboronic acid CHLOROPHOSPHONAZO III DIETHOXYMETHANE Ethoxy Droloxifene