| Company Name: |
Biolab Reagents
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| Tel: |
027-65279366 18108604356 |
| Email: |
products@biolabreagent.com |
| Products Intro: |
Product Name:SETD2
Purity:95% SDS-PAGE Package:1mg;100ug
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| | SET domain containing 2 Basic information |
| Product Name: | SET domain containing 2 | | Synonyms: | Anti-SETD2 antibody produced in goat;Anti-KMT3A antibody;SET2;FLJ45883;FLJ16420;FLJ22472;FLJ23184;SET domain containing 2 | | CAS: | | | MF: | | | MW: | 0 | | EINECS: | | | Product Categories: | | | Mol File: | Mol File | ![SET domain containing 2 Structure]() |
| | SET domain containing 2 Chemical Properties |
| storage temp. | -20°C | | form | buffered aqueous solution | | biological source | human |
| | SET domain containing 2 Usage And Synthesis |
| Uses | Useful for the study of enzyme kinetics, screening inhibitors, and selectivity profiling. | | Biological Activity | SET domain containing 2 (SETD2) plays a vital role in trimethylation of the histone mark H3K36 (histone 3 lysine 36). Mutation of this tumor suppressor gene (TSG) is associated with the pathogenesis of various cancers including, clear cell renal cell carcinoma (cRCC), breast cancer, lung cancer, acute lymphoblastic leukemia(ALL), and glioma. In addition, SETD2 gene is also involved in the development of Huntingtonμs disease (HD). SETD2 plays an important role in the transcriptional elongation by maintaining chromatin structure through association with hyperphosphorylated RNA polymerase II (POLR2A). SETD2 interacts with p53 and act as a tumor suppressor in breast cancer cells. SETD2 is implicated in DNA double-strand break (DSB) exclusion and homologous recombination (HR) repair in human cells. SETD2 in HeLa cells alters nucleosome organization via decreasing the recruitment of the FACT (facilitates chromatin transcription) complex to active genes. |
| | SET domain containing 2 Preparation Products And Raw materials |
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