ChemicalBook > Product Catalog >API >Circulatory system drugs >Angina Pectoris Drugs >Nicorandil

Nicorandil

Nicorandil Suppliers list
Company Name: Capot Chemical Co.,Ltd.
Tel: +86 (0)571-855 867 18
Email: sales@capotchem.com
Products Intro: Product Name:Nicorandil
CAS:65141-46-0
Purity:98%(Min,HPLC) Package:100g;1kg;5kg,10kg,25kg,50kg
Company Name: Henan DaKen Chemical CO.,LTD.
Tel: +86-371-55531817
Email: info@dakenchem.com
Products Intro: Product Name:Nicorandil
CAS:65141-46-0
Purity:99.00% Package:100g,500g,1KG,10KG,100KG
Company Name: Henan Tianfu Chemical Co.,Ltd.
Tel: 0371-55170693
Email: info@tianfuchem.com
Products Intro: CAS:65141-46-0
Purity:99% Package:500G;1KG;5KG;25KG
Company Name: Shanghai Time Chemicals CO., Ltd.
Tel: +86-021-57951555
Email: jack.li@time-chemicals.com
Products Intro: Product Name:Nicorandil
CAS:65141-46-0
Company Name: Chemwill Asia Co.,Ltd.
Tel: 86-21-51086038
Email: chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com
Products Intro: CAS:65141-46-0
Purity:99% Package:5KG;1KG;25KG PRICE quotation Remarks:Factory stock, quality assurance, price concessions
Nicorandil Basic information
Product Name:Nicorandil
Synonyms:NICORANDIL;PERISALOL;SIGMART;IKOREL;ADANCOR;2-nicotinamidoethylnitrate;n-(2-(nitrooxy)ethyl)-3-pyridinecarboxamid;n-(2-hydroxyethyl)nicotinamidenitrate(ester)
CAS:65141-46-0
MF:C8H9N3O4
MW:211.17
EINECS:265-514-1
Product Categories:Pharmaceutical;-;Intermediates & Fine Chemicals;Pharmaceuticals;Potassium channel;Aromatics;Heterocycles;Ikorel;reagent;Cardiovascular APIs
Mol File:65141-46-0.mol
Nicorandil Structure
Nicorandil Chemical Properties
Melting point 92°C
Boiling point 350.85°C (rough estimate)
density 1.4271 (rough estimate)
RTECS US4667600
refractive index 1.7400 (estimate)
storage temp. Desiccate at +4°C
solubility DMSO: >10mg/mL
pkapKa 空 (Uncertain)
form powder
color white to off-white
Merck 14,6521
CAS DataBase Reference65141-46-0
Safety Information
Hazard Codes Xn
Risk Statements 22-41
Safety Statements 26-39
WGK Germany 3
HS Code 29333990
ToxicityLD50 in rats (mg/kg): 1200-1300 orally; 800-1000 i.v. (Nagano)
MSDS Information
Nicorandil Usage And Synthesis
DescriptionNicorandil is a coronary vasodilator useful in the treatment of angina pectoris. Decreases in left ventricular end diastolic pressure and systemic vascular resistance also appear to contribute to the anti-ischemic effects of the drug.
Chemical PropertiesWhite solid
OriginatorChugai (Japan)
UsesAn antianginal
UsesAntihypertensor
DefinitionChEBI: A pyrimidinecarboxamide that is nicotinamide in which one of the hydrogens attached to the carboxamide nitrogen is replaced by a 2-(nitrooxy)ethyl group. It has both nitrate-like and ATP-sensitive potassium channel activator properties, and is used for the prevention and treatment of angina pectoris.
Brand nameSIGMART; PERISALOL
Biological ActivityK ATP channel opener and NO donor, clinically used as antianginal agent. Preferentially activates SUR2B- versus SUR2A-containing K ATP channels (EC 50 values are 10 and > 500 mM respectively) and causes 1.6-fold increase in cardiac eNOS expression. Displays coronary and peripheral vasodilatory properties, reduces both pre- and after-load, and increases coronary blood flow. Also displays cardioprotective effects, possibly through ischemic preconditioning.
Nicorandil Preparation Products And Raw materials
Raw materialsNitric acid-->Ethanolamine-->2-N-BUTOXYETHYL METHACRYLATE-->Methyl nicotinate-->NICOTINOYL CHLORIDE HYDROCHLORIDE
Tag:Nicorandil(65141-46-0) Related Product Information
1-(2,6-Dimethylphenoxy)-2-propanamine Nicorandil(SubjectToPatentFree)6514146-0 NICORANDIL = N[2-(NITROOXY)ETHYL]3-PYRIDINECARBOXAMIDE NICORANDIL Nicorandil fumaric acid salt NICORANDIL-D4,NICORANDIL-D4 (PYRIDYL-D4) 3-Pyridinecarboxaldehyde-D4 Aminoethyl nitrate N-(2-HYDROXYETHYL)NITOTINAMIDE NICOTINAMIDE-2,4,5,6-D4 Nicorandil Etanol Ethylparaben Ethyl acrylate Ethyl vanillin Ethyl 4'-hydroxy-3'-methoxycinnamate Ethyl acetate Ethyl nitrate